Biostatistics and Bioinformatics Core

由德克萨斯大学SPORE提出的肺癌研究涵盖了广泛的肺癌转化研究活动，包括细胞系，异种移植和转基因动物模型，临床和分子注释的肿瘤和其他生物标本，种系多态性和临床试验。这些研究将产生许多不同类型的数据，包括临床、流行病学、生物化学、免疫组化、剂量反应、基因表达微阵列、测序等。Core提供全面的专业知识，以确保SPORE在德克萨斯大学西南医学中心（UTSW）进行的研究的统计完整性、数据完整性、数据共享和数据分析。安德森癌症中心（MDACC）和俄亥俄州州立大学（OSU）。核心在每个机构都有一名董事（UTSW的Xie，MDACC的Baladandayuthapani和OSU的Coombes），并且可以灵活地将人员与现有和发展中的SPORE项目不断变化的需求相匹配。核心成员参加每月的SPORE视频会议，将德克萨斯州达拉斯的UTSW、德克萨斯州休斯顿的MDACC和俄亥俄州的哥伦布的OSU的研究人员联系起来，确保在SPORE实验的所有阶段适当考虑生物统计学和数据管理问题。核心将开发和维护数据存储、检索、分析和共享系统。它将为SPORE的所有调查人员提供一个接口。核心服务是通过积累的经验，积累的计算机代码和资源，以及创新的，独特的，有时定制的方法来解决现代数据中心研究实验室中的数据分析和解释挑战。为履行其职责，核心委员会有以下具体目标： 目标1：提供从SPORE正在进行的研究中产生的实验室研究、临床试验和转化实验的有效统计设计。目标二：监督和进行创新的统计建模，模拟，数据分析和数据整合所需的项目，发展和职业项目，以及其他核心，以实现其特定目标。A im 3：确保所有项目的结果都基于精心设计的实验，并进行适当的解释，并协助编写描述这些结果的手稿。A im 4：为SPORE项目提供一个数据存储和分发的综合网站，特别是那些涉及全基因组和其他数据密集的项目。

The research proposed by The University of Texas SPORE in Lung Cancer encompasses a broad range of lung cancer translational research activities, including studies in cell lines, xenografts and transgenic animal models, clinically and molecularly annotated tumor and other biospecimens, germline polymorphisms, and clinical trials. These studies will generate many different types of data, including clinical, epidemiological, biochemical, immunohistochemical, dose response, gene expression microarrays, sequencing, and more. The Core provides comprehensive expertise to ensure the statistical integrity, data integrity, data sharing, and data analysis of the studies performed by the SPORE, which are conducted at the University of Texas Southwestern Medical Center (UTSW), the M.D. Anderson Cancer Center (MDACC) and Ohio State University (OSU). The Core has a director at each institution (Xie at UTSW, Baladandayuthapani at MDACC, and Coombes at OSU) and has the flexibility to match personnel to the evolving needs of existing and developmental SPORE Projects. Members of the Core participate in monthly SPORE vide conferences linking researchers at UTSW in Dallas, TX, MDACC in Houston, TX and OSU in Columbus, Ohio, ensuring that proper consideration is taken of biostatistics and data management issues during all phases of SPORE experiments. The Core will develop and maintain systems for data storage, retrieval, analysis, and sharing. It will provide an interface for all SPORE investigators. The Core services are made possible by the accumulated experience, accumulated computer codes and resources, and by innovative, unique, sometimes customized approaches to solving the data analysis and interpretation challenges in the modern data centric research laboratory. To carry out its responsibilities, the Core has the following Specific Aims: Aim 1: To provide valid statistical designs of laboratory research, clinical trials and translational experiments arising from the ongoing research of the SPORE. Aim 2: To oversee and conduct the innovative statistical modeling, simulations, data analyses and data integration needed by the Projects, Developmental and Career Projects, and the other Cores to achieve their specific aims. A im 3: To ensure that the results of all Projects are based on well-designed experiments, appropriately interpreted, and to assist in the preparation of manuscripts describing these results. A im 4: To provide an integrated site for data storage and distribution for the SPORE Projects, particularly those with genome-wide and other data-dense Projects.