New England Regional Coordinating Center for the NINDS Stroke Trials Network

描述（由申请人提供）：我们建议创建新英格兰区域协调中心（NERCC），这是一个由波士顿和马萨诸塞州西部的医院和EMS机构组成的综合团队，将作为NINDS卒中试验网络的顶级招募网站和充满活力的贡献者。我们的团队包括大波士顿地区的许多主要成人学术中风中心，我们的30家新英格兰医院的远程中风转诊网络将进一步扩大我们的潜在招聘。所有核心医院都有成功管理和临床试验绩效的良好记录。特别是，所有医院都有一个既定的研究基础设施，通过跨学科的强有力合作，在中风神经病学方面进行持续的临床研究。首席研究员Lee H. Schwamm，MD和合作研究者带来了一套互补的技能，管理成功的转化临床研究计划，指导委员会成员资格，以及在各自领域的国家领导地位。我们的团队包括血管神经病学、急诊医学、神经血管内、神经外科、神经重症监护、神经影像学、卒中康复以及成人和儿童临床前基础和转化卒中研究方面经验丰富的临床研究人员。NERCC团队的优势包括：1）多名研究者之间密切的个人和专业联系; 2）来自不同医院的大量患者人群 在大都市地区的设置; 3）有才华的研究中心研究人员团队，具有多中心试验中的科学成就，创新和受试者招募的跟踪记录; 4）强大的现有NINDS资助的研究和临床试验管理基础设施; 5）现有的临床研究计划，例如，神经病学临床研究所，波士顿大学和哈佛的NIH临床和转化科学奖项目;急性卒中转化研究专业项目（SPOTRIAS）和神经病学紧急治疗试验和NeuroNEXT临床协调中心。此外，将利用与波士顿和伍斯特院前服务的整合来支持NERCC的目标。总的来说，NERCC团队有资源、愿景和热情来开发新的转化科学，并成功执行NINDS卒中试验网络1期、2期和3期研究。

DESCRIPTION (provided by applicant): We propose to create the New England Regional Coordinating Center (NERCC), an integrated team of hospitals and EMS agencies in Boston and Western Massachusetts that will serve as a top-enrolling site and vibrant contributor to the NINDS Stroke Trials Network. Our group includes many of the major adult academic stroke centers in the Greater Boston area, and our 30 hospital New England TeleStroke referral network will extend our potential recruitment even further. All core hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across disciplines. Principal investigator Lee H. Schwamm, MD, and Co-Investigators bring a complementary set of skills in managing successful translational clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation i both adults and children. Strengths of the NERCC team include 1) close personal and professional ties between multiple investigators; 2) large patient population from diverse hospital settings in a major metropolitan area; 3) talented teams of site investigators with track records o scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure; 5) existing clinical research programs, e.g., Neurology Clinical Research Institute, NIH Clinical and Translational Science Award programs at Boston University and across Harvard; Sites in the Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) and Neurology Emergency Treatment Trials and NeuroNEXT Clinical Coordinating Center. In addition, integration with Boston and Worcester prehospital services will be leveraged to support the goals of the NERCC. Overall, the NERCC Team has the resources, vision, and enthusiasm to develop new translational science and successfully execute the NINDS Stroke Trials Network Phase 1, 2 and 3 studies.