Integrated approaches to targeting G protein-coupled receptors: Translational studies of novel drug-receptor paradigms

该奖学金的重点是在人体中发现的最大的蛋白质家族之一，即所谓的“G蛋白偶联受体”（GPCR）。GPCR控制着我们每个细胞之间的通信方式，几乎与所有疾病都有关系。该提案将研究将药物靶向GPCR的新机制，这些机制可以克服目前的药物发现瓶颈，并导致治疗神经精神，心血管，炎症和代谢疾病的新方法。

This Fellowship focuses on one of the largest family of proteins found in the human body, the so-called ‘G protein-coupled receptors ‘ (GPCRs). GPCRs control how each of our cells communicates with one another, and have been implicated in virtually all diseases. This proposal will study new mechanisms of targeting drugs to GPCRs that can overcome current drug discovery bottlenecks and lead to new ways of treating neuropsychiatric, cardiovascular, inflammatory and metabolic diseases.