Understanding G Protein-Coupled Receptors (GPCRs): Accelerating Discovery from Concept to Clinic.

了解 G 蛋白偶联受体 (GPCR)：加速从概念到临床的发现。

• 批准号: nhmrc : 519461
• 负责人: Prof Arthur Christopoulos
• 金额: $ 458.21万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Programs
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-g-protein-concept-clinic/78163
• 关键词: Understanding; Protein; Coupled; Receptors; GPCRs

G Protein-Coupled Receptors (GPCRs) form the largest family of receptors (and thus drug targets) in living organisms. Currently, the major reason that new drugs fail to reach the clinic is lack of appropriate drug effect (approx. 30%). Thus, we need a better understanding of how GPCRs work and how this relates to disease. Our Program addresses this knowledge gap, using GPCR models that are relevant to treatment of metabolic, cardiovascular and central nervous system disease.

G蛋白偶联受体(GPCRs)是生物体中最大的受体家族(从而形成药物靶标)。目前，新药未能进入临床的主要原因是缺乏适当的药物效果(约.30%)。因此，我们需要更好地了解GPCRs是如何工作的，以及这与疾病有何关系。我们的项目利用与新陈代谢、心血管和中枢神经系统疾病的治疗相关的GPCR模型来解决这一知识差距。