Research Fellowship: Understanding G protein-coupled receptors (GPCRs)

研究奖学金：了解 G 蛋白偶联受体 (GPCR)

• 批准号: nhmrc : 1041875
• 负责人: Prof Arthur Christopoulos
• 金额: $ 29.62万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/research-fellowship-understanding-receptors-gpcrs/111408
• 关键词: Research; Fellowship; Understanding; protein; coupled

This project focuses on drug action at G protein-coupled receptors (GPCRs), the largest class of drug targets. It builds on key discoveries by the applicant that novel sites on GPCRs can be targeted by small molecules in a selective manner, thus minimizing side effects and maximizing therapeutic efficacy. Because this approach can work across most GPCR families, the relevance to the pharmaceutical industry and GPCR-related diseases, such as schizophrenia and diabetes, is very high.

该项目主要研究药物在G蛋白偶联受体（gpcr）上的作用，这是最大的一类药物靶点。它建立在申请人的关键发现之上，即小分子可以选择性地靶向gpcr上的新位点，从而最大限度地减少副作用并最大化治疗效果。由于这种方法可以适用于大多数GPCR家族，因此与制药行业和GPCR相关疾病（如精神分裂症和糖尿病）的相关性非常高。