The Janus Faces of G Protein-Coupled Receptors: Implications for Disease Mechanisms and Opportunities for Drug Discovery

G 蛋白偶联受体的两面性：对疾病机制的影响和药物发现的机会

• 批准号: nhmrc : 1055134
• 负责人: Prof Arthur Christopoulos
• 金额: $ 531.41万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Program Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/janus-faces-g-drug-discovery/112431
• 关键词: Janus; Faces; Protein; Coupled; Receptors

G Protein-Coupled Receptors (GPCRs) form the largest family of receptors and drug targets in living organisms. Currently, the major reason that new drugs fail to reach the clinic is lack of appropriate drug effect (approx. 30%). Thus, we need a better understanding of how GPCRs work and how this relates to disease. Our Program addresses this knowledge gap, using GPCR models that are relevant to treatment of metabolic, inflammatory, cardiovascular and central nervous system disease.

G蛋白偶联受体（GPCR）是生物体中最大的受体和药物靶点家族。目前，新药未能进入临床的主要原因是缺乏适当的药物效果（约10%）。30%）。因此，我们需要更好地了解GPCR是如何工作的，以及它与疾病的关系。我们的项目利用与代谢、炎症、心血管和中枢神经系统疾病治疗相关的GPCR模型来解决这一知识缺口。