FASEB SRC on post-transcriptional control of gene expression: Mechanisms of mRNA

描述(申请人提供)：对信使核糖核酸降解对基因表达至关重要的认识可以追溯到1959年，当时帕迪·雅各布和莫诺德在一篇历史论文中证明，必须有一个不稳定的中间体来指导蛋白质合成。最近，RNAi用于实验降解特定的mRNAs的壮观使用已经扩展了理解mRNAs衰变机制的应用，超出了任何预期。因此，信使核糖核酸的降解显然对基因表达具有重要意义，全面了解信使核糖核酸的降解机制及其调控对于理解生物医学问题和产生新的生物医学研究工具具有明显的应用价值。FASEB关于信使核糖核酸衰变机制的会议已经发展成为一次独特的会议，汇聚了后生动物、真菌、植物、细菌和古生物系统中信使核糖核酸衰变的领先专家。虽然我们对转录及其调控如何有助于基因表达有了透彻的了解，但我们对基因表达中转录后步骤的理解是不完整的。这次FASEB会议的几乎每一次迭代都包括了与mRNA衰退有关的新酶的揭示，2014年的会议可能还会发现更多的酶。例如，在2012年的最后一次会议上，讨论了表明Dis3l2参与mRNA衰退的第一个结果。因此，关于mRNA降解的机制仍有许多有待发现的地方，而对其机制的完整理解显然是理解调控的先决条件。为了实现增加我们对mRNA降解机制的理解这一广泛而长期的目标，我们将于2014年7月6日至11日在蒙大拿州的大天空继续举行一系列科学会议。2014年会议是FASB组织的系列会议中的第9次，该系列会议是继上世纪90年代S组织的类似会议之后由ASM组织的。这一系列会议对该领域产生了重大影响，并具有特殊的价值，2012年会议的与会者中有96%在评估表上表示计划参加2014年会议，36名受邀发言者中只有1人拒绝了我们对2014年会议的邀请，以及所附会议主席对即将举行的会议的支持信。我们希望通过三个具体目标来实现这一目标

DESCRIPTION (provided by applicant): The understanding that mRNA degradation is critical for gene expression traces back to 1959 when Pardee Jacob and Monod demonstrated in a historical paper that there had to be an unstable intermediate directing protein synthesis. More recently, the spectacular use of RNAi to experimentally degrade specific mRNAs has expanded the applications of understanding mRNA decay mechanisms beyond any expectations. Thus, mRNA degradation is clearly of fundamental importance to gene expression, and a complete understanding of mRNA degradation mechanisms and its regulation has clear applications for understanding biomedical problems and for generating new tools for biomedical research. The FASEB meeting on mechanisms of mRNA decay has developed into a unique conference that brings together the leading experts in mRNA decay in metazoan, fungal, plant, bacterial, and archaeal systems. Although we have a thorough understanding of how transcription and its regulation contribute to gene expression, our understanding of post-transcriptional steps in gene expression is incomplete. Almost every iteration of this FASEB meeting has included revelations of new enzymes involved in mRNA decay, and more may remain to be discovered for the 2014 meeting. For example, at the last meeting in 2012 the first results that indicated that DIS3L2 was involved in mRNA decay were discussed. Thus, much remains to be discovered about the mechanism of mRNA degradation, and a complete understanding of the mechanism is an obvious pre-requisite to understanding regulation. Towards the broad and long-term goal of increasing our understanding of the mechanisms of mRNA degradation we are continuing a series of scientific meetings from July 6th to 11th 2014 in Big Sky, Montana. The 2014 meeting is the 9th in a series organized by FASEB, which followed similar meetings organized by ASM in the 90's. This series of meetings has had a major impact on the field and is exceptionally valued as evidenced by the fact that 96% of the attendees of the 2012 meeting indicated that they planned to attend the 2014 meeting on the evaluation form, that only 1 of the 36 invited speakers declined our invitation for the 2014 meeting, and by the enclosed support letters of session chairs for the upcoming meeting. We hope to achieve this goal through three specific aims