Enhanced Surveillance for New Vaccine Preventable Disease

项目总结/摘要 本合作协议的目的是支持网站网络， 关于新疫苗使用情况、新疫苗的影响以及 即将推出的疫苗和其他免疫预防，新的疫苗政策和政策 正在考虑，通过加强住院和急诊部（艾德） 监测，应用流行病学研究，和卫生机构发起的调查。 新的疫苗监测网络（NVSN）将致力于实现2020年健康人群目标 免疫和传染病的优先领域，特别是减少或 消除疫苗可预防的疾病和评估疫苗接种覆盖率， 普遍推荐的疫苗。 NVSN计划的目的是利用基于人口的站点网络， 积极监察急性肠胃炎，并提供一个架构， 研究其他重要的疫苗相关问题。 主要重点将是描述轮状病毒感染的负担和流行病学 导致住院和艾德访视年龄在15天至11岁之间， 积极监察急性肠胃炎。积极监察急性肠胃炎 将在2个环境（医院和艾德）中进行，以确定 急性胃肠炎和轮状病毒在每一个这些设置，并检查趋势， 时间（许可前和许可后）。11岁以下儿童住院或在医院接受护理 将筛选有AGE症状的艾德，如果符合资格，则邀请其参加研究 标准，并同意进行研究。人口统计学和临床数据将于 所有入学的孩子。将采集粪便标本并进行轮状病毒检测。数据将 分析以估计基于人群的轮状病毒住院率和艾德就诊率， 儿童急性胃肠炎的临床和流行病学特征 由于轮状病毒，利用本研究获得的轮状病毒病例进行应用 轮状病毒疫苗有效性和成本的流行病学评价 轮状病毒病，并检查其他病原体，如诺如病毒的负担， 通过这一监测系统获得的特征良好的数据和样本。

PROJECT SUMMARY/ABSTRACT The purpose of this cooperative agreement is to support a network of sites that provide surveillance and data collection on new vaccine use, the impact of the new vaccines and upcoming vaccines and other immunoprophylaxis, new vaccine policies and policies under consideration, through enhanced inpatient and emergency department (ED) surveillance, applied epidemiologic research, and investigator-initiated investigations. This New Vaccine Surveillance Network (NVSN) will address the Healthy People 2020 priority area for immunization and infectious diseases, specifically, the reduction or elimination of vaccine preventable diseases and evaluating vaccination coverage for universally recommended vaccines. The intent of the NVSN program is to utilize a network of population-based sites to conduct active surveillance for acute gastroenteritis in addition to providing a framework in which to study other important vaccine related questions. The major focus will be to describe the burden and epidemiology of rotavirus infection resulting in hospitalization and ED visits between 15 days and 11 years of age using active surveillance for acute gastroenteritis. Active surveillance for acute gastroenteritis will be conducted in 2 settings (hospital and ED) to determine the disease burden of acute gastroenteritis and rotavirus in each of these settings and to examine trends over time (pre- and post-licensure). Children <11 years of age hospitalized or cared for in the ED with symptoms of AGE will be screened, invited to participate if they meet eligibility criteria and consented for the study. Demographic and clinical data will be collected on all enrolled children. A stool specimen will be collected and tested for rotavirus. Data will be analyzed to estimate population-based rotavirus hospitalization and ED visit rates, to characterize the clinical and epidemiologic factors of children with acute gastroenteritis due to rotavirus, to utilize rotavirus cases obtained through this study to conduct applied epidemiologic evaluations of the effectiveness of rotavirus vaccines and costs of rotavirus disease and to examine the burden of other pathogens such as norovirus using the well characterized data and specimens obtained through this surveillance system.