Molecular Mechanisms of Immune Tolerance

项目描述： 我们要求重新支持以分子为重点的博士后培训计划 免疫耐受和自身免疫的机制。该应用程序来自 以免疫学综合系为中心的高度互动的教职员工 教职员工非常专注于B和T细胞的发展，抗原识别， 开发、编辑沉默、删除和无能为力以及理解 自身免疫力。综合免疫学系由65名教职员工组成 (初级和二级)来自三个机构：国家犹太人健康，芭芭拉 戴维斯儿童糖尿病中心(BDC)和科罗拉多大学医学院 医学。在20名培训教员中，近一半已被招聘到该部门 自1999年成立以来，所有培训教师都得到了NIH RO1赠款的支持 他们是首席调查员。我们请求为4名研究员提供津贴支持，他们将 在他们选择的实验室培训，这些实验室的研究重点是免疫耐受 和自身免疫力。这些研究员将参加定期安排的日记俱乐部， 正在进行的研究研讨会、正式研讨会和课程，例如关于道德和生存 科学技能，他们的进展将由一个培训监督委员会监督 (TOC)。实习生的任期为一年，只有在经过评审后才能连任。 目标为本课程取得重大进展。我们的目标是为学员提供 全面了解免疫耐受和自身免疫的小鼠模型， 和对临床自身免疫的充分了解，使他们能够发展成 富有成效的临床合作纽带，促进研究成果的转化。项目总监是 John Cambier博士，Ida和Cecil Green特聘教授兼 综合免疫学系。坎比尔博士是B细胞信号方面的专家， 激活和无能，并已培训了60多名研究生和 博士后研究员。培训计划拥有一流的研究设施和 教职员工在培训和研究方面都是互动的。虽然丹佛航空公司 免疫学社区已经培训了30多名博士后和博士后研究员 多年来，成立了免疫学综合系并聘用了新的教员 产生了强大的凝聚力，为 我们的教育和研究活动。这一培训计划是该计划的中心重点 活力。

PROJECT DESCRIPTION: We request renewed support for a postdoctoral training program focused on molecular mechanisms of immunologic tolerance and autoimmunity. The application comes from a highly interactive faculty centered in the Integrated Department of Immunology whose faculty is strongly focused on B and T cell development, antigen recognition, repertoire development, silencing by editing, deletion and anergy, and understanding autoimmunity. The Integrated Department of Immunology is comprised of 65 faculty (primary and secondary) from three institutions: the National Jewish Health, The Barbara Davis Center for Childhood Diabetes (BDC) and The University of Colorado School of Medicine. Nearly half of the 20 training faculty have been recruited to the Department since its inception in 1999, and all training faculty are supported by NIH RO1 grants on which they are Principal Investigator. We request stipend support for 4 fellows who will train in laboratories of their choosing whose research is focused of immune tolerance and autoimmunity. The fellows will participate in regularly scheduled journal clubs, research in progress seminars, formal seminars and courses, e.g. on ethics and survival skills in science, and their progress will be monitored by a training oversight committee (TOC). Trainees will be appointed for one year and reappointed only if they are judged by the TOC to be making significant progress. Our goal is to provide fellows with comprehensive knowledge of immune tolerance and mouse models of autoimmunity, and sufficient understanding of clinical autoimmunity to enable their development of productive clinical collaborative ties for translation of research. The Program Director is Dr. John Cambier, Ida and Cecil Green Distinguished Professor and Chairman of the Integrated Department of Immunology. Dr. Cambier is an expert in B cell signaling, activation and anergy, and has trained in excess of 60 graduate students and postdoctoral fellows. The training program has available superb research facilities and the faculty, are interactive in both training and research. Although the Denver immunology community has been training pre- and postdoctoral fellows for over 30 years, formation of the Integrated Department of Immunology and hiring of new faculty has provided a strongly uniting influence, and injected new excitement and vitality into our educational and research activities. This training program is a central focus of that vitality.