Computational modeling of human metabolism, body weight and composition

我们继续开发人类新陈代谢的数学模型，并使用各种已发表的数据进行了几项验证研究，这些数据涉及饮食中大量营养素的过度喂养、喂养不足和等卡路里变化的代谢反应。我们的模型已被部署为http://bwsimulator.niddk.nih.gov的在线体重模拟器，以帮助设计前瞻性研究以及计划和跟踪临床体重管理计划。我们的模型被应用于各种问题，从计算人体体重变化与食物摄入量之间的关系，到使用频繁的体重测量来计算自由生活能量摄入量的变化。我们还使用我们的模型来帮助解决政策问题，例如汽水税可能对美国肥胖率的影响。

We continue to develop mathematical models of human metabolism and have conducted several validation studies using a variety of published data on the metabolic responses to overfeeding, underfeeding, and isocaloric changes in dietary macronutrients. Our models have been deployed as an online body weight simulator at http://bwsimulator.niddk.nih.gov to help design prospective studies as well as plan and track clinical weight management programs. Our models are being applied to a variety of problems, from calculating the relationship between human weight change and food intake to calculating changes of free-living energy intake using frequent body weight measurements. We have also used our models to help address policy issues such as the likely effect of soda taxes on US obesity prevalence.