Administrative Coordinating Core - URBAN ARCH Consortium

描述（由申请人提供）：在艾滋病毒流行的第四个十年中，关于酒精使用如何影响艾滋病毒临床表现以及抗逆转录病毒疗法以外的治疗如何减轻酒精相关危害的许多问题仍然存在。需要解决有关艾滋病毒和酒精之间复杂关系的这些问题，以便加速开发更有效的治疗方法。乌干达-俄罗斯-波士顿酒精研究艾滋病毒/艾滋病合作网络（URBAN ARCH）联盟将在行政协调核心（行政核心）的领导下开展队列和干预研究，以解决我们对艾滋病毒和酒精的理解差距。URBAN ARCH联盟的中心目标是研究酒精对艾滋病毒疾病的影响并减轻其有害影响。为了实现这一目标，URBAN ARCH联盟将整合流行病学、内科医学、成瘾医学、艾滋病毒/艾滋病、精神病学和生物统计学方面的研究人员的专业知识，在艾滋病毒和临床成瘾医学领域的领导者联盟PI的领导下。该联盟的研究将以来自波士顿、乌干达和俄罗斯的三个现有的艾滋病毒感染队列为基础，这些队列具有独特的优势和明确的酒精消费模式。这两个国际队列允许研究在美国不可能进行的临床问题，但对美国hiv感染人群具有重要意义。管理核心的目标是确保URBAN ARCH联盟的科学和规划目标以高质量和及时性实现。因此，行政核心将实现以下具体目标：促进合作，综合方法的研究目标；促进所有联盟成员之间的建设性沟通和创造性合作；协调和优先考虑对资源的访问，包括URBAN ARCH数据和样本库；评估组件的进度和质量，以最大限度地发挥联盟的科学影响；鼓励与联盟内外的调查人员共享数据。行政核心目标的实现将最大限度地提高URBAN ARCH联盟的整体生产力，并实现杰出的多机构、跨学科和国际合作的潜力。在与联盟所有组成部分的合作中，管理核心将确保遵守预先计划的目标，并支持与联盟目标一致的科学探究的新发展路线。

DESCRIPTION (provided by applicant): In the fourth decade of the HIV epidemic, many questions remain about how alcohol use affects HIV clinical manifestations and how treatments beyond ART might mitigate alcohol-related harms. Such questions about the complex relationship between HIV and alcohol need to be addressed in order to accelerate the development of more effective treatments. The Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium will carry out cohort and intervention studies under the leadership of the Administrative Coordinating Core (Admin Core) to address gaps in our understanding about HIV and alcohol. The central goal of the URBAN ARCH Consortium is to examine the consequences of alcohol on HIV disease and to mitigate its harmful effects. To realize this goal, the URBAN ARCH Consortium will incorporate the expertise of researchers in epidemiology, internal medicine, addiction medicine, HIV/AIDS, psychiatry and biostatistics, under the leadership of a Consortium PI who is a leader in the field of HIV and clinical addiction medicine. The Consortium studies will build on three existing HIV- infected cohorts from Boston, Uganda, and Russia with distinctive strengths and well-characterized alcohol consumption patterns. The two international cohorts allow study of clinical issues that would not be possible in the United States, yet have important implications for US HIV-infected populations. The objective of the Admin Core is to ensure that the scientific and programmatic goals of the URBAN ARCH Consortium are achieved with high quality and timeliness. Accordingly, the Admin Core will accomplish the following Specific Aims: Promote a collaborative, integrated approach to research goals; Facilitate constructive communication and creative collaboration between all Consortium components; Coordinate and prioritize access to resources including the URBAN ARCH data and sample repository; Assess components' progress and quality to maximize the scientific impact of the Consortium; Encourage the sharing of data to investigators within and outside the Consortium. The accomplishment of the Admin Core's aims will maximize the overall productivity of the URBAN ARCH Consortium and realize the potential of the outstanding multi-institutional, inter-disciplinary, and international collaborations. In working with all of the Consortium components, the Admin Core will ensure adherence to preplanned aims and support new evolving lines of scientific inquiry consistent with the Consortium's goal.