Integrative systems pharmacology, neutron reflectometry and molecular dynamics approaches to unravelling the interactions between polymyxins and bacterial membranes

肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌是导致全球范围内危及生命的感染的6种最优先危险的超级细菌之一。这项研究将使用多学科的方法来破译多粘菌素与这三种超级细菌的膜的复杂相互作用，并发现具有更好疗效的新型抗生素。这一创新项目的目标是由于抗生素耐药性而导致的紧迫的、尚未得到满足的全球医疗危机。

Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii are among the 6 top-priority dangerous ‘superbugs’ causing life-threatening infections worldwide. This study will employ a multi-disciplinary approach to decipher the complex interactions of polymyxins with the membranes of these three ‘superbugs’ and to discover novel antibiotics with superior efficacy. This innovative project targets the urgent unmet global medical crisis due to antibiotic resistance.