New England Regional Coordinating Center for the NINDS Stroke Trials Network

描述（由申请人提供）：我们建议建立新英格兰地区协调中心（NERCC），这是一个由波士顿和马萨诸塞州西部的医院和EMS机构组成的综合团队，将成为NINDS卒中试验网络的顶级注册站点和活跃贡献者。我们的团队包括大波士顿地区许多主要的成人学术中风中心，我们的30家医院新英格兰卒中转诊网络将进一步扩大我们的潜在招聘。所有核心医院都有成功管理和临床试验表现的良好记录。特别是，所有医院都有一个已建立的研究基础设施，在卒中神经学方面进行持续的临床研究，并有跨学科的强有力合作。首席研究员Lee H. Schwamm医学博士和联合研究者在管理成功的转化临床研究项目、指导委员会成员和各自领域的国家领导职位方面提供了一套互补的技能。我们的团队包括血管神经学、急诊医学、神经血管内、神经外科、神经重症监护、神经影像学、中风康复以及成人和儿童临床前基础和转化中风研究方面经验丰富的临床研究人员。NERCC团队的优势包括：1)多名调查人员之间密切的个人和专业关系；2)来自不同医院的大量患者

DESCRIPTION (provided by applicant): We propose to create the New England Regional Coordinating Center (NERCC), an integrated team of hospitals and EMS agencies in Boston and Western Massachusetts that will serve as a top-enrolling site and vibrant contributor to the NINDS Stroke Trials Network. Our group includes many of the major adult academic stroke centers in the Greater Boston area, and our 30 hospital New England TeleStroke referral network will extend our potential recruitment even further. All core hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across disciplines. Principal investigator Lee H. Schwamm, MD, and Co-Investigators bring a complementary set of skills in managing successful translational clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation i both adults and children. Strengths of the NERCC team include 1) close personal and professional ties between multiple investigators; 2) large patient population from diverse hospital settings in a major metropolitan area; 3) talented teams of site investigators with track records o scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure; 5) existing clinical research programs, e.g., Neurology Clinical Research Institute, NIH Clinical and Translational Science Award programs at Boston University and across Harvard; Sites in the Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) and Neurology Emergency Treatment Trials and NeuroNEXT Clinical Coordinating Center. In addition, integration with Boston and Worcester prehospital services will be leveraged to support the goals of the NERCC. Overall, the NERCC Team has the resources, vision, and enthusiasm to develop new translational science and successfully execute the NINDS Stroke Trials Network Phase 1, 2 and 3 studies.