Imaging and Biomarkers in Adolescents Cleared for Return to Play After Concussion

描述（由申请人提供）：这项前瞻性观察性研究提出了一个总体假设，即无症状的高中运动员在运动脑震荡（SC）后一个月出现脑功能障碍和结构性损伤，这些运动员已被许可的健康提供者（LHP）批准恢复比赛（RTP）。我们假设在招募当天从血清中测量的生物标志物是sc后一个月恢复的预后。高中运动员将在sc后三天内招募（n=24），这些运动员将从休斯敦纪念赫尔曼运动医学诊所连续转诊。还将招募24名患有骨科损伤（OI）的高中运动员作为对照组。每周通过电话对脑震荡后症状进行评估，以确定一个月后无症状并清除RTP的运动员。损伤后1个月，两组均返回临床进行神经行为评估、磁共振成像（MRI）、弥散张量成像（DTI）和静息状态功能磁共振成像（fmri）测量脑区功能连通性（FC）。数据分析将测试脑区域白质束（DTI）和FC完整性的组间差异。生物标志物水平将被分析

DESCRIPTION (provided by applicant): This prospective, observational study addresses the overarching hypothesis that brain dysfunction and structural injury are present at one month post- sports concussion (SC) in asymptomatic high school athletes who have been cleared by a licensed health provider (LHP) for return to play (RTP). We hypothesize that a biomarker measured from serum on the day of recruitment is prognostic of recovery by one month post-SC. High school athletes will be recruited within three days post-SC (n=24) from consecutive referrals to Memorial Hermann Sports Medicine Clinic in Houston. A comparison group of 24 high school athletes with orthopedic injury (OI) will also be recruited. Weekly assessment via telephone of post-concussion symptoms will identify athletes who are asymptomatic by one month and cleared for RTP. At one month post-injury both groups will return to clinic for neurobehavioral assessment, magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and resting state functional magnetic resonance imaging to measure functional connectivity (FC) of brain regions. Data analysis will test between-group differences in integrity of white matter tracts (DTI) and FC of brain regions. Biomarker levels will be analyzed in relation to brain imaging and neurobehavioral recovery at one month in SC group.