CAREER DEVELOPMENT IN DIABETES RESEARCH FOR PEDIATRIC ENDOCRINOLOGISTS

描述（由申请人提供）：本申请旨在通过Joslin糖尿病中心和波士顿儿童医院的联合机构职业发展计划，促进多样化和训练有素的儿科内分泌学家群体进入儿科糖尿病研究领域的职业发展。通过对已完成儿科内分泌学研究的儿科内分泌学者进行指导培训，该联合项目将支持和培养与1型糖尿病相关的生物医学和行为糖尿病研究的初级教师的职业发展。基于Joslin糖尿病中心和波士顿儿童医院之间的长期合作历史，我们广泛的糖尿病研究项目，以及在我们最近完成的K12儿科糖尿病专家职业发展资助的支持下，我们成功的儿科内分泌学家成为独立的糖尿病研究人员的职业发展记录，我们的目标是指导一群新的儿科内分泌学家，他们将成为美国儿科糖尿病项目的未来领导者。每年，我们将为3名儿科内分泌学奖学金项目的应届毕业生提供长达3年的职业发展和支持。乔斯林糖尿病中心和波士顿儿童医院非常适合这个机构职业发展奖，因为我们有广泛的教师导师团队，多学科培训计划，致力于指导博士前和博士后研究员以及与1型糖尿病相关的初级教师研究，以及我们的可用的多样化，有才华的候选人被任命为K12项目。申请的理由包括：儿童1型和2型糖尿病发病率的增加，发现1型和2型糖尿病的根本原因的需要，在青年时期实现最佳血糖控制的挑战，短期和长期糖尿病并发症的高风险，需要进一步研究以增加我们对罕见遗传形式糖尿病的理解，实施和维持强化胰岛素治疗的需求以及儿童新的监测技术，并且需要训练有素和有责任心的儿童糖尿病研究者来推进旨在治疗、预防和治愈这些疾病的研究。鉴于我们机构的糖尿病研究历史和哈佛医学院环境的丰富性，该联合申请为致力于儿科糖尿病事业的儿科内分泌学家的职业发展提供了独特的环境。联合首席研究员和项目主任Lori Laffel MD MPH和联合首席研究员Morris White博士在咨询委员会的支持下，处于协调这一努力的最佳位置。乔斯林的美国国立卫生研究院支持的糖尿病研究中心（前身为DERC）、哈佛大学的CTSA和哈佛大学的催化剂项目加强了职业发展。我们一直表现出吸引高素质候选人参加我们的培训项目的能力，并期待迎接培养儿科内分泌学家作为儿科糖尿病研究者的职业挑战。

DESCRIPTION (provided by applicant): This application aims to foster the career development of a diverse and exceptionally well trained group of pediatric endocrinologists entering the field of pediatric diabetes research through a joint institutional career development program at the Joslin Diabetes Center and Children's Hospital Boston. Through mentored training of pediatric endocrine scholars who have completed fellowships in pediatric endocrinology, this joint program will support and nurture career development of junior faculty in biomedical and behavioral diabetes investigation relevant to type 1 diabetes. Based upon the longstanding history of collaboration between the Joslin Diabetes Center and Children's Hospital Boston, our extensive diabetes research programs, and our record of successful career development of pediatric endocrinologists becoming independent diabetes researchers with support from our recently completed K12 career development grant for pediatric diabetologists, we aim to mentor a new group of pediatric endocrinologists who will become future leaders of pediatric diabetes programs in the United States. Each year we will provide career development and support for up to 3 years for 3 recent graduates of pediatric endocrinology fellowship programs. The Joslin Diabetes Center and the Children's Hospital Boston are ideally suited for this institutional career development award due to our extensive group of faculty mentors, multi-disciplinary training programs, commitment to mentoring pre- doctoral and post-doctoral fellows and junior faculty in research relevant to type 1 diabetes, and our available pool of diverse, talented candidates for appointment to the K12 program. The rationale for the application includes: the increased occurrence of both type 1 and type 2 diabetes in childhood, the need to discover the root causes of type 1 and type 2 diabetes, the challenges of achieving optimal glycemic control in youth, the high risk of short- and long-term diabetes complications, the need for additional research to increase our understanding of uncommon genetic forms of diabetes, the demands of implementing and maintaining intensive insulin therapy and new monitoring technologies in children, and the need for trained and committed pediatric diabetes investigators to advance research aimed at treating, preventing and curing these disorders. Given the history of diabetes research at our institutions and the richness of the Harvard Medical School environment, this joint application offers a unique setting for career development of pediatric endocrinologists committed to careers in pediatric diabetes. Co-Principal Investigator and Program Director Lori Laffel MD MPH and Co-Principal Investigator Morris White PhD, supported by an Advisory Committee, are in optimal positions to orchestrate this endeavor. Career development is enhanced by Joslin's NIH-supported Diabetes Research Center (formerly DERC), Harvard's CTSA, and Harvard's Catalyst Program. We have consistently demonstrated the ability to attract highly qualified candidates to our training programs and look forward to meeting the challenge of nurturing the careers of pediatric endocrinologists as pediatric diabetes investigators.