Alliance NCORP Research Base

描述（由申请人提供）：联盟NCI社区肿瘤研究计划（NCORP）研究基地开展介入性和观察性临床试验以及数据库分析，解决有关癌症预防，筛查，症状干预，治疗后监测/生存，生活质量和癌症护理提供的重要问题。我们特别强调影响少数群体，服务不足和老年患者群体的问题，并与NCORP社区站点和少数群体/服务不足社区站点建立牢固的大学关系。肿瘤临床试验联盟（联盟）是五个国家临床试验网络（NCTN）小组之一，是所有NCORP研究基地试验的协调中心。联盟成员代表社区实践和学术医疗中心的数量大致相等，因此试验的结果广泛反映了美国各地患者的实际经验。为了提高我们对癌症风险和恶性前病变的生物学基础，检测症状前新诊断或复发恶性肿瘤的生物标志物，以及癌症相关症状和治疗相关毒性的生理机制的理解，我们的大多数临床试验包括需要收集肿瘤组织，恶性前组织样本，血液或其他人类生物标本的转化研究问题。这些生物标本为理解实验室和临床观察之间的联系创造了宝贵的资料库。联盟NCORP研究基地与其他NCORP研究基地广泛合作，招募患者参加试验，进行转化研究，并共享数据和生物标本进行汇总分析。我们还与其他nci资助的研究人员和联盟，以及通过非nci来源支持的研究人员广泛合作。在过去的五年中，联盟研究者的努力已经产生了超过99篇摘要和手稿，其中许多在临床实践中产生了显著的有益变化。联盟NCORP研究基地所回答的科学问题代表了对生物医学科学的有意义和创新的贡献，并且只能通过公共资助的研究网络来解决。

DESCRIPTION (provided by applicant): The Alliance NCI Community Oncology Research Program (NCORP) Research Base conducts interventional and observational clinical trials as well as database analyses addressing important questions concerning cancer prevention, screening, symptom intervention, post-treatment surveillance/survivorship, quality of life and cancer care delivery. We place special emphasis upon issues affecting minority, underserved and elderly patient groups, and upon building strong collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance for Clinical Trials in Oncology (Alliance), one of the five National Clinical Trials Network (NCTN) groups, serves as the coordinating center for the conduct of all NCORP Research Base trials. The Alliance members represent community practices and academic medical centers in approximately equal number, so the results of the trials broadly reflect the actual experience of patients across the United States. In order to improve our understanding of the biological basis of cancer risk and pre-malignant disease, biomarkers that detect pre-symptomatic newly diagnosed or recurrent malignancies, as well as the physiologic mechanisms of cancer-related symptoms and treatment-related toxicities, most of our clinical trials include translational research questions requiring the collection of tumor tissue, premalignant tissue samples, blood, or other human biospecimens. These biospecimens create an invaluable repository for understanding the associations between laboratory and clinical observations. The Alliance NCORP Research Base collaborates broadly with other NCORP Research Bases to enroll patients in trials, conduct translational studies, and share data and biospecimens for pooled analyses. We also collaborate broadly with other NCI-funded investigators and consortia, as well as investigators supported through non-NCI sources. Results of Alliance investigator efforts have resulted in more than 99 abstracts and manuscripts over the past five years, many resulting in significant beneficial changes in clinical practice. The scientific questions answered by the Alliance NCORP Research Base represent meaningful and innovative contributions to biomedical sciences, and can only be addressed through a publicly-funded research network.