The Johns Hopkins Cancer Nanotechnology Training Center

摘要 我们建议创建一个癌症医学纳米技术博士前培训项目--约翰·霍普金斯癌症纳米技术培训中心(CNTC)--该项目将定位于癌症生物学和纳米技术的交界处，并将建立一个独特的全国性资源，在癌症医学的基础研究和翻译研究方面都有跨学科和协同计划。CNTC将培养将接受跨学科培训的博士前研究员，为能够深入了解癌细胞功能的技术奠定基础，而不是目前使用的有限的黑盒输入-输出技术，引入分子成像的新模式，开发新的高通量诊断工具，并设计新型病毒和非病毒递送系统来治疗人类癌症。CNTC研究员将从物理、生物和生物医学角度观察纳米结构和生物系统之间的相互作用，并将熟练掌握生物分子工程、蛋白质工程、材料合成和表面修饰方面的新兴概念，这些概念需要创造纳米技术来阐明和实时监测导致癌症转化的信号通路。CNTC成员还将开发新的癌症诊断方法，根据患者的遗传和表观遗传标记以及为每个患者选择和优化的疾病表型和治疗方法，评估每个患者的预后和最佳治疗。国家技术委员会将培训一批博士前研究员，为未来在学术界和工业研究实验室进行研究做准备。通过独立的提案撰写，国家技术委员会将强调研究的早期独立性。CNTC研究员将能够利用约翰霍普金斯医院、NCI指定的Sidney Kimmel综合癌症中心、路德威克癌症遗传学和治疗中心、Sol Goldman胰腺癌中心、活体细胞和分子成像中心、约翰霍普金斯肿瘤学中心PSOC的研究和临床资源，以及约翰霍普金斯纳米生物技术研究所的独特教育资源和实验设施，CNTC将以行政管理的方式设在该研究所。

Summary We propose to create a predoctoral training program in nanotechnology for cancer medicine - The Johns Hopkins Cancer Nanotechnology Training Center (CNTC) - that will be positioned at the interface of cancer biology and nanotechnology and will establish a unique national resource with interdisciplinary and synergistic programs in both fundamental and translational research in cancer medicine. The CNTC will foster predoctoral fellows who will be trained across disciplines to lay foundations for technologies that will enable an inside-view of cancer cell functions as opposed to the limited black-box input-output techniques currently used, introduce new modalities for molecular imaging, develop new high-throughput diagnostic tools, and engineer novel viral and non-viral delivery systems to treat human cancers. CNTC fellows will view interactions between nanostructures and biological systems in physical, biological, and biomedical terms and will become adept at emerging concepts in biomolecular engineering, protein engineering, materials synthesis and surface modification, which are required to create nanotechnology to elucidate and monitor in real-time signaling pathways that lead to cancer transformation. CNTC fellows will also develop novel cancer diagnostics to evaluate each individual patient's prognosis and optimal treatment, based upon the patients' genetic and epigenetic markers and disease phenotype and therapeutics that are selected and optimized for each individual patient. The CNTC will train a cadre of predoctoral fellows for a future in research in academia and research laboratories in industry. Through independent proposal writing, the CNTC will emphasize early independence in research. CNTC fellows will be able to take advantage of research and clinical resources at the Johns Hopkins Hospital, the NCI- designated Sidney Kimmel Comprehensive Cancer Center, the Ludwick Center for Cancer Genetics and Therapeutics, The Sol Goldman Pancreatic Cancer Center, the In Vivo Cellular and Molecular Imaging Center, and the Johns Hopkins Engineering in Oncology Center PSOC as well as the unique educational resources and experimental facilities of the Johns Hopkins Institute for NanoBioTechnology, where the CNTC will be administratively housed.