Optimizing Graphic Warning Labels To Promote Cessation Among Young Adult Smokers

描述（由申请人提供）：此NCI K 07职业发展奖申请旨在为申请人Darren Mays，PhD，MPH提供成为一名独立调查员所需的指导经验，该调查员具有与烟草监管政策相关的行为烟草控制科学专业知识。拟议的培训和研究活动由烟草相关癌症和烟草政策评估的生物行为框架指导，并将使我能够获得与尼古丁成瘾，戒烟和烟草监管相关的交叉领域的新专业知识。我的职业发展将由具有生物行为癌症和烟草控制科学专业知识的导师（Kenneth Tercyak博士; Raymond Niaura博士）指导，并由跨学科的专家顾问团队提供信息。培训活动将包括通过乔治敦大学医学中心、乔治敦隆巴迪综合癌症中心、遗产施罗德研究所和其他当地学术研究机构的独特资源提供的教学和应用技能部分。拟议的研究通过调查图形香烟警告标签和普通（即，在18-30岁的年轻成年吸烟者中，2009年《家庭吸烟预防和烟草控制法》是美国烟草控制政策的关键一步，要求新的图形健康警告标签取代烟盒上现有的纯文字警告。该法案还提供了一个框架，如果有证据支持使用香烟包装品牌，则实施有关香烟包装品牌的额外规定。年轻的成年吸烟者是这个研究领域的一个高度优先群体：他们很容易受到烟草业通过香烟包装促销的影响，并且有很高的风险成为上瘾的吸烟者，但他们是一个研究严重不足的群体。我的培训将帮助我设计和执行行为研究，以解决这个烟草控制证据库的重要问题。K 07的研究部分补充了我提出的培训活动，并将通过调查警告信息框架的影响来帮助推进烟草监管科学（增益或损失框架）和普通香烟包装，以降低销售点购买香烟的吸引力（目标1）和对吸烟行为和戒烟动机的短期预期影响（目标2），研究生物行为调节和中介机制。透过前瞻性跟进，我们亦会评估警告标签信息框和普通包装对戒烟影响的长期持久性，为日后制定R 01（目的3）提供数据。通过应用新的实验方法，本研究将产生关于香烟包装法规对吸烟行为影响的数据。这是NCI和NIH合作烟草监管科学计划的一个高度优先研究领域。这个K 07的经验将使我准备从事独立的研究，重点是行为烟草控制科学和监管政策，以预防美国烟草相关癌症。

DESCRIPTION (provided by applicant): This NCI K07 career development award application is designed to provide the applicant, Darren Mays, PhD, MPH, with the mentored experiences needed to become an independent investigator with expertise in behavioral tobacco control science relevant to tobacco regulatory policy. The proposed training and research activities are guided by a biobehavioral framework for tobacco-associated cancers and tobacco policy evaluation and will position me to gain new expertise in cross-cutting areas related to nicotine addiction, smoking cessation, and tobacco regulation. My career development will be guided by mentors with expertise in biobehavioral cancer and tobacco control science (Kenneth Tercyak, PhD; Raymond Niaura, PhD) and informed by an interdisciplinary team of expert consultants. Training activities will include didactic and applied skills components available through the unique resources of Georgetown University Medical Center, Georgetown Lombardi Comprehensive Cancer Center, Legacy's Schroeder Institute, and other local academic research institutions. The proposed research complements these career development activities by investigating the impact of graphic cigarette warning labels and plain (i.e., unbranded) cigarette packaging among young adult smokers ages 18-30. The 2009 Family Smoking Prevention and Tobacco Control Act was a critical step in U.S. tobacco control policy, requiring new graphic health warning labels to replace existing text-only warnings on cigarette packs. The Act also provides the framework to implement additional regulations on cigarette pack branding if evidence supports their use. Young adult smokers are a high priority group for this research area: they are vulnerable to tobacco industry promotions via cigarette packs and have a high risk of becoming addicted smokers, yet they are a sorely under-researched group. My training will help me design and execute behavioral research to address questions important to this tobacco control evidence base. The research component of this K07 complements my proposed training activities and will help to advance tobacco regulatory science by investigating the impact of warning message framing (gain- or loss-framed) and plain cigarette packaging for reducing the appeal of point-of-sale cigarette purchases (Aim 1) and the short-term prospective impact on smoking behaviors and motivation to quit (Aim 2), examining biobehavioral moderating and mediating mechanisms. Through prospective follow up, we will also assess the long-term durability of the impact of warning label message framing and plain packaging on smoking cessation to inform the development of a future R01 (Aim 3). By applying novel experimental methods, this study will generate data on the impact of cigarette packaging regulations on smoking behavior. This is a high priority research area for the NCI and the NIH collaborative Tobacco Regulatory Science Program. The experiences of this K07 will prepare me to pursue independent research focusing on behavioral tobacco control science and regulatory policy to prevent tobacco-associated cancers in the U.S.