Path to Improved Risk Stratification

心脏性猝死是一个主要的公共卫生问题，大约有18万到 每年有40万人死亡。由于Out-Out-Out的疗效和成功率较低 医院复苏，已经设定了高度优先的任务，试图识别有风险的人 在事件发生前因心源性猝死。如果可以做到这一点，就有治疗方法。 可以用来减轻这一风险的措施。然而，尽管进行了数十年的研究， 投入大量的时间、精力和研究经费，目前还没有一个理想的或 甚至可以接受的心脏性猝死风险分层方法。一种方法 为了在这一领域取得更快进展而发起的行动是为了更好地促进 不同利益相关者之间的协调-调查人员、政府机构和 工业。尽管所有人都有风险分层的需要，但每一组都有 不同的优先顺序，因此从不同的角度处理问题 透视。改善风险分层的途径，NFP是一个非营利性智库 由杰弗里·戈德伯格博士创立，他的使命是作为联络人帮助 组织合理、协调的发展计划、评估计划和 实施预防心脏性猝死的风险分层策略。 在改善风险分层的道路上，NFP组织了一年一度的单日 过去八年在芝加哥参加的会议：1)风险领域的医生领导 分层、预防心脏性猝死的临床试验、流行病学和 卫生经济学；2)有关政府机构的代表；3) 来自工业界的代表。会议议程旨在确定重要的 因此，我们有必要了解我们知识中的差距，并制定如何最好地填补这些差距的战略。这些 会议在风险分层方面产生了新的努力，并帮助指导了一些 已经在开发中的临床试验。每次会议的议程是 评估前一次会议的进展情况，审查与风险相关的新信息 分层，讨论与正在进行的临床试验相关的问题，获得规划的最新情况 在新试验中，审查与风险分层有关的科学/统计/经济学问题， 并探索在我们的知识库中存在空白的新领域。考虑到地球的辽阔 需要理解的信息，以推进风险分层领域，这 努力为参与者提供了一个重要的试听板，并鼓励 合作和创新方法的发展。

Sudden cardiac death is a major public health problem with approximately 180,000 to 400,000 deaths annually. Because of the low efficacy and success rates of out-of- hospital resuscitation, a high priority has been set to try and identify individuals at risk for sudden cardiac death prior to the event. If this can be done, there are treatments that can be instituted to mitigate this risk. However, despite decades of research, and significant investments of time, effort, and research dollars, there is not yet an ideal or even acceptable approach to risk stratification for sudden cardiac death. One approach that could be initiated to engender more rapid progress in this area is to promote better coordination among the various stakeholders - investigators, government agencies, and industry. Although all are vested in the need for risk stratification, each group has different sets of priorities and therefore approaches the problem from different perspectives. The Path to Improved Risk Stratification, NFP is a not-for-profit think tank founded by Dr. Jeffrey Goldberger whose mission is to serve as a focal point to help organize a rational, coordinated plan for developing, evaluating, and implementing risk stratification strategies for prevention of sudden cardiac death. The Path to Improved Risk Stratification, NFP has organized annual single day meetings in Chicago for the last eight years with: 1) physician leaders in the area of risk stratification, clinical trials in prevention of sudden cardiac death, epidemiology, and health economics; 2) representatives from the relevant government agencies; 3) representatives from industry. The meeting agendas are designed to identify important gaps in our knowledge and to strategize how those gaps can best be filled. These meetings have resulted in new efforts in risk stratification and have helped guide some clinical trials that have been in development. The agenda for each meeting is to evaluate progress from the prior meeting, review new information relevant to risk stratification, discuss issues related to ongoing clinical trials, obtain updates on planning of new trials, review scientific/statistical/economics issues related to risk stratification, and explore new areas that are gaps in our knowledge base. Given the vastness of the information that needs to be understood to advance the field of risk stratification, this effort provides an important sounding board for those involved and encourages collaboration and the development of innovative approaches.