Administrative Core

行政核心的总体目标是为以下方面提供领导和组织骨干 这项建议，促进项目和核心之间的合作，并协调与 外部实体，如国家心肺血液研究所(NHLBI)和食品和药物管理局 管理局(FDA)。为了实现这些目标，我们提出了以下具体任务。 具体任务1：促进项目1-3与核心A和B之间的沟通，并协助所有 在手稿准备和提交方面的项目，以及协助科学家在 PubMed Central。 具体任务2：提供威斯康星大学、NHLBI、 以及内部和外部项目审查员。 具体任务3：通过与 威斯康星大学健康科学机构审查委员会(IRB)和FDA。 行政核心将通过组织与本提案中的所有项目和核心进行互动， 每月内部项目审查会议的通知和会议纪要的分发。这个 行政核心将监督科目应收率，以确保每个项目能够满足其 所需样本大小。核心将负责编写和提交年度进度报告。 向研究所提供咨询，并将视需要组织外部和内部审查。最后，核心将与 FDA关于新药(IND)建议使用节段性药物的申请 使用屋尘螨、猫或豚草变应原激发过敏原。 相关性(请参阅说明)： 这一核心的总体目标是为整个计划项目赠款提供行政支持。通过 提供这种支持，每个项目和剩余的核心可以专注于完成其提议的研究 科学问题，以满足这笔赠款的总体目标。

The overall goals ofthe Administrative Core are to provide leadership and the organizational backbone for this proposal, promote collaboration between the projects and cores, and coordinate interactions with external entities such as the National Heart, Lung, and Blood Institute (NHLBI) and the Food and Drug Administration (FDA). To accomplish these goals, we propose specific tasks listed below. Specific Task 1: To facilitate communication among Projects 1-3 and Cores A and B and to assist all projects in manuscript preparation and submission as well as assist scientists in registering manuscripts on PubMed Central. Specific Task 2: To provide mechanisms for communication between the University of Wisconsin, NHLBI, and internal and external project reviewers. Specific Task 3: To provide regulatory support to all projects and cores through interactions with the University of Wisconsin Health Sciences Institution Review Board (IRB) and the FDA. The Administrative Core will interact with all projects and cores in this proposal through organization, notification, and distribution of meeting minutes of monthly internal project review meetings. The Administrative Core will oversee the rate of subject accrual to ensure that each project is able to meet its required sample size. The core will be responsible for preparation and submission of annual progress reports to the Institute and will organize external and internal reviews as needed. Finally, the core will work with the FDA with regard to an Investigational New Drug (IND) application for the proposed use of segmental bronchoprovocation with allergen using house dust mite, cat, or ragweed allergen. RELEVANCE (See instructions): The overall objective of this core is to provide administrative support for the entire program project grant. By providing this support, each project and remaining core can focus on completing research for their proposed scientific questions to meet the overall goal of this grant.