Interactions between IL-15 and TGF-beta signalling pathways reveal novel therapeutic strategies to boost anti-cancer immunity
Interactions between IL-15 and TGF-beta signalling pathways reveal novel therapeutic strategies to boost anti-cancer immunity
IL-15 和 TGF-β 信号通路之间的相互作用揭示了增强抗癌免疫的新治疗策略
批准号：
nhmrc : GNT1140406
负责人：
Dr Fernando de Souza Fonseca Guimaraes
金额：
$44.44万
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2018
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2018-01-01 至 --
中文摘要
翻译
该项目将确定新的免疫抑制检查点是否可以与BRAFV 600 E抑制协同靶向，以重新激活并允许NK细胞最大化其抗肿瘤免疫功能并防止癌症扩散。这是一种全新的方法，将允许更合理地设计手术和局部放疗和/或化疗后靶向NK细胞的黑色素瘤治疗。
英文摘要
This project will determine if new immune inhibitory checkpoints can be synergistically targeted with BRAFV600E inhibition to reactivate and allow NK cells to maximise their anti-tumour immune functions and prevent cancer spread. It is a completely novel approach that will allow for the more rational design of melanoma treatments that targets NK cells following surgery and local radiotherapy and/or chemotherapy.
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会议论文
Deciphering IFN type III, TGFβ, IL-10 and adenosine pathways in natural killer cells: enhancing the innate anti-metastatic response against breast cancer progression
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批准号：nhmrc : GNT1088703
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项目类别：Early Career Fellowships
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资助金额：$30.94万
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财政年份：2015
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负责人：Dr Fernando de Souza Fonseca Guimaraes
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依托单位：
海外基金
