Interactions between Neuropeptide FF receptor and hypothalamic neuropeptides in the regulation of energy homeostasis and obesity

尽管肥胖症流行令人担忧，但目前还没有有效的长期治疗肥胖症的方法。神经肽FF及其受体NPFF2R在调节食物摄入和体脂储存方面具有新兴作用。这项研究的结果将显示NPFF2R是否在调节食欲、代谢率、体重和脂肪储存方面发挥重要作用，从而有助于确定NPFF2R靶向疗法是否会为肥胖的长期治疗带来显著益处。

Despite the alarming obesity epidemic, there currently exists no effective long-term treatment for obesity. Neuropeptide FF and its receptor NPFF2R have an emerging role in regulating food intake and body fat stores. Results from this study will show whether NPFF2R plays an important role in regulating appetite, metabolic rate, body weight and fat stores, thus help to identify whether NPFF2R-targeted therapeutics would confer significant benefit for the long-term treatment of obesity.