Interactions between RAGE and the type 1 angiotensin receptor determine the pro-atherosclerotic actions of angiotensin II

心脏病发作和中风是澳大利亚人死亡和残疾的主要原因。肾素血管紧张素系统的激活在动脉粥样硬化的发生和发展中起着关键作用，动脉粥样硬化是导致动脉狭窄和阻塞的过程。根据初步数据，我们已经找到了一种阻断这些通路而不影响血压控制的方法。我们相信，基于这些数据的干预措施将对心脏病的预防和治疗非常重要。

Heart attacks and strokes are a major cause of death and disability in Australians. Activation of the renin angiotensin system plays a key role in the development and progression of atherosclerosis, the process that leads to narrowing and obstruction of arteries. In preliminary data we have found a way to block these pathways without affecting the control of blood pressure. We believe that interventions based on these data will be important for the prevention and treatment of heart disease.