Interdisciplinary Training Program in Muscle Biology

描述（由申请人提供）：该计划提供肌肉生物学的跨学科培训，为前和博士后学生。该计划强调骨骼，心脏和平滑肌的功能，结构和分子特性，以及在各种疾病状态下这些特性的修改。我们的17名教师来自3个基础科学部门（生物化学和分子生物学，药理学和实验治疗学和生理学）和医学系在医学院，马里兰州巴尔的摩大学（UMB），和1名来自护理学院，UMB。附属教师也来自工程学院的一个部门在我们的姐妹校区，马里兰州巴尔的摩县大学和摩根州立大学。学员来自所有参与部门和我们的跨部门博士课程。反映我们的教师背景的多样性，提供的培训范围从肌肉发育的分子生物学决定因素和肌肉蛋白质的结构和功能的分子方面，通过肌肉细胞骨架和基质的细胞生物学方面，单个肌肉细胞功能的生物物理和生理分析，以及整个肌肉和肌肉器官的生物力学特性，以及肌肉疾病对所有这些检查水平的影响。我们的教师在肌肉功能和肌肉细胞骨架和基质的钙控制领域得到国内和国际认可。我们的学生将在这些和各种相关领域接受培训，重点是使用几种补充技术来解决每个调查中的问题。博士前培训的主要教学方面是两个一学期的跨学科肌肉课程，这些课程已经由计划教师定期提供，并受到过去学生团体的好评。计划活动包括每年的校园迷你务虚会，其中包括实习生海报和著名的肌肉研究人员作为计划访问者和主讲人，半年度韦德纪念讲座和每月肌肉计划实验室回合午餐会议为所有学员，以及培训专业发展和赠款写作，并在研究的负责任的行为。 我们将继续在我们目前的水平，5个博士前学员和6个博士后学员在整个续约期间。进入博士前培训生将继续在生物学，化学和/或物理学，优秀的GRE成绩和强有力的推荐信坚实的背景。即将到来的博士后培训生将完成扎实的博士论文，并有强有力的推荐信。该计划的学员将准备采取各种方法来回答肌肉生物学中的基本问题，以及肌肉疾病及其可能的治疗和最终治愈的基础。因此，该计划满足了国家对肌肉功能和疾病的多学科研究人员的需求。

DESCRIPTION (provided by applicant): This program provides interdisciplinary training in muscle biology for pre- and postdoctoral students. The program emphasizes the functional, structural and molecular properties of skeletal, cardiac and smooth muscle, and the modification of these properties in various disease states. 17 of our faculty members come from 3 basic science departments (Biochemistry and Molecular Biology, Pharmacology and Experimental Therapeutics and Physiology) and from the Department of Medicine at the School of Medicine, University of Maryland Baltimore (UMB), and 1 from the School of Nursing, UMB. Affiliate faculty also come from 1 department in the College of Engineering at our sister campus, University of Maryland Baltimore County and from Morgan State University. Trainees are drawn from all of the participating departments and from our interdepartmental PhD Programs. Reflecting our diversity of faculty backgrounds, the training offered ranges from the molecular biological determinants of muscle development and molecular aspects of structure and function of muscle proteins through cell biological aspects of muscle cytoskeleton and matrix, biophysical and physiological analysis of individual muscle cell function and biomechanical properties of whole muscles and muscular organs, and the effects of muscle disease at all these levels of examination. Our faculty is nationally and internationally recognized in the areas of calcium control of muscle function and muscle cytoskeleton and matrix. Our students will receive training in these and in a variety of related areas, with emphasis on the use of several complimentary techniques to approach each question under investigation. The major didactic aspect of the predoctoral training is two one- semester interdisciplinary courses on muscle that are already regularly offered by the program faculty and which have been well received by past student groups. Program activities include an annual on campus Mini-Retreat which includes trainee posters and a well known muscle researcher as program visitor and keynote speaker, a semi annual Wade Memorial lectureship and monthly Muscle Program Laboratory Rounds lunch meetings for all trainees, as well as training in professional development and grant writing, and in the responsible conduct of research. We will continue at our present level of 5 predoctoral trainees and 6 postdoctoral trainees throughout the renewal period. Entering predoctoral trainees will continue to have a solid background in biology, chemistry and/or physics, excellent GRE scores and strong letters of recommendation. Incoming postdoctoral trainees will have completed a solid PhD thesis and have strong letters of recommendation. Trainees from this program will be prepared to bring a wide range of approaches to bear on answering basic questions in muscle biology and on the bases for muscle diseases and their possible treatment and eventual cure. This program therefore serves a national need for competent multi-disciplinary investigators of muscle function and disease.