The comparative physiology of oxygen delivery to the kidney

肾脏处于高氧的危险中，因为相对于其质量，肾脏接收了如此多的血液。有人提出，在动脉和静脉之间分流氧气基本上减轻了高氧的风险，但在某些情况下，分流基本上增加了肾脏缺氧的风险。利用同步加速器和组织学成像的结合，本项目将仔细定义几个不同物种的肾皮质的三维血管系统，并使用计算建模解释其功能意义。该项目的成果将是一个新的理解，在比较生理学的氧气运输和分流在肾脏。

The kidney is in danger of hyperoxia because the kidney receives so much blood relative to its mass. It is proposed that shunting oxygen between arteries and veins substantially mitigates the risk of hyperoxia, but under certain circumstances shunting substantially increases the risk of kidney hypoxia. Using a combination of synchrotron and histological imaging, This project will carefully define the three-dimensional vasculature of the renal cortex in several different species and interpret its functional significance using computational modeling. The outcome of this project will be a new understanding in the comparative physiology of oxygen transport and shunting in the kidney.