Training in HIV Replication and Pathogenesis

描述(由申请人提供)：艾滋病毒-1仍然是导致全球发病率和死亡率的最重要的传染病原因之一。最近的研究成果使艾滋病毒/艾滋病研究处于一个激动人心的时期--但要想继续取得进展，就需要训练有素的专家科学家进行跨学科的协作努力。这项提议的目标是让年轻科学家为这一角色做好准备，并培训下一代艾滋病毒/艾滋病研究人员。学员将掌握广泛的技能和知识，包括病毒学、分子生物学和免疫学，以及有关指导、科学写作、尖端研究技术和其他对其职业发展至关重要的问题的培训。自上一次申请竞争更新以来，我们拓宽了可用的研究机会，将此培训计划与罗切斯特大学(UR)S艾滋病研究新发展中心及其临床与翻译科学研究所(CTSI)整合，增加了针对艾滋病毒/艾滋病的新课程，并设计了创新的同行/近同行评估流程，以促进学员的职业发展。我们还增加了一个外部咨询委员会，以协助监督该计划。该计划有4个具体目标。第一：建立一个互动的、富有成效的和令人振奋的跨学科环境，使博士前培训生在艾滋病毒/艾滋病研究方面获得出色的教育。这将通过整合来自多个系和学科的教员来实现。第二：利用UR新的艾滋病研究发展中心(DCFAR)及其临床与翻译科学研究所(CTSI)创造的资源和机会。这将通过使用新的课程、研讨会和尖端科学核心设施来实现。第三：为学生提供一个丰富的培训和学习环境，包括有组织的研讨会计划、杰出的校外演讲者、职业发展活动、针对艾滋病毒/艾滋病的课程、支持受训人员职业发展的创新同行/近同行评估过程、加强负责任的研究行为培训以及指导培训机会。学生还将接受科学写作方面的培训，重点是手稿和拨款申请。第四：通过上述计划促进学员和教职员工之间的沟通。这将利用UR医学院和牙科学院提供的亲密环境，所有参与的教职员工和受训人员在同一物理空间、同一屋檐下共同工作。总体而言，该计划将在三个主要重点领域提供出色的培训机会：(I)病毒复制、RNA生物学和逆转录，(Ii)病毒免疫学和疫苗生物学，以及(Iii)病毒发病机制(重点是神经艾滋病)。

DESCRIPTION (provided by applicant): HIV-1 remains one of the most important infectious causes of global morbidity and mortality. Recent research successes make this an exciting time in HIV/AIDS research - but continued progress will require interdisciplinary, collaborative efforts by highly trained, expert scientists. The goal of this proposal is to prepare young scientists for that role, and to train the next generation of HIV/AIDS researchers. The trainees will be equipped with a broad range of skills and knowledge including virology, molecular biology and immunology as well as training in mentoring, scientific writing, cutting edge research techniques, and other issues important to their career development. Since the previous competitive renewal of this application, we have broadened the research opportunities available, integrated this training program with the University of Rochester (UR)'s new Developmental Center for AIDS Research (DCFAR) and its Clinical & Translational Science Institute (CTSI), added new HIV/AIDS-specific courses, and designed an innovative peer/near-peer evaluation process to enhance trainee career development. We have also added an External Advisory Board to assist with oversight of this program. The program has 4 specific objectives. First: To develop an interactive, productive and exciting interdisciplinary environment in which predoctoral trainees obtain an outstanding education in HIV/AIDS research. This will be achieved by integrating faculty from multiple departments and disciplines. Second: To leverage resources and opportunities created by the UR's new Developmental Center for AIDS Research (DCFAR) and its Clinical & Translational Science Institute (CTSI). This will be achieved by accessing new courses, seminars and cutting-edge scientific core facilities. Third: To provide an enriched training and learning environment for students, with structured seminar programs, distinguished extramural speakers, career development activities, HIV/AIDS-specific courses, an innovative peer/near-peer evaluation process to support trainee career development, enhanced training in the responsible conduct of research, and opportunities for training in mentoring. Students will also be trained in scientific writing, with emphasis on manuscripts and grant applications. Fourth: To foster communication among trainees and faculty through the programs outlined above. This will exploit the intimate environment provided at the UR School of Medicine and Dentistry, where all the participating faculty and trainees work together in the same physical space, under a single roof. Overall, the program will provide outstanding training opportunities in three major emphasis areas: (i) viral replication, RNA biology and reverse transcription, (ii) viral immunology and vaccine biology, and (iii) viral pathogenesis (with emphasis on neuroAIDS).