Cell Signaling of Host Defense

由迈克尔·B·费斯勒医学博士领导的国家环境健康科学研究所内壁研究部呼吸生物学实验室的宿主防御小组自成立以来已进入第九个年头。在过去的一年里，费斯勒博士获得了NIH内部研究项目的终身教职。自上次年度报告以来出版的出版物包括： 1)一份合作报告显示，免疫相关GTP酶Irgm1在细胞内的定位受其与脂肪酸棕榈酸酯的修饰控制(Henry等人，PLoS one。2014年4月21日；9(4)：e95021)。 2)一份资深作者的报告显示，肿瘤抑制因子p53和转录因子NF-kB合作在原代人类巨噬细胞中诱导促炎细胞因子(Lowe等人，癌症研究，2014年4月15日；74(8)：2182-92)。 3)共同第一作者的报告显示载脂蛋白E调节小鼠模型中急性肺损伤的发展(Yamashita等人，呼吸。2014年；87(5)：416-27)。 4)一位资深作者的报告表明，人类基因APOE的epsilon 4等位基因(即APOE4)与人类炎症反应的增强有关(Gale等人，J Allative Clin免疫。2014年7月；134(1)：127-134.e9)。 5)一份合作报告显示，胆固醇转运体Abcg1控制巨噬细胞上细胞外胆固醇结构域的生成，这一发现与胆固醇转运体相关(Freeman等，J Lipid Res.2014年1月；55(1)：115-27)。 6)关于低密度脂蛋白对中性粒细胞功能的急性和慢性影响的合作报告(Palvinskaya T等人，Pulm Pharmacol Ther，2013)。 7)第一作者报告称，血清胆固醇与美国公民的红细胞指数(如红细胞压积)和血小板指数(如血小板计数)有关(Fessler等人，J Lipid Res.2013 11；54(11)：3177-88)。 8)一位资深作者报告说，清道夫受体B-I调节肺宿主对感染的防御(Gowdy等人，Mucosal免疫学，2014，在印刷中)。 自上次报告以来，我们还取得了其他成就，包括Fessler博士在NIH细胞因子兴趣小组脂质调节剂在炎症中的会议(2014)上的特邀演讲，国家咨询环境健康科学委员会第142次会议，以及NC Assoc的科学素养处方研讨会。用于生物医学研究。费斯勒博士还在2014年美国胸科学会国际会议上担任海报会议主持人。自上次报告以来，Fessler博士的几名实习生也获得了奖项/认可，包括博士后研究员Kymberly Gowdy(第二名，博士后伙伴海报竞赛，访问肺学者研讨会，北卡罗来纳州大学星期五中心；在2014年ATS国际会议上的口头报告)，以及研究生Michael Henderson(北卡罗来纳大学毒理学课程研究生最佳海报演示文稿)。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its ninth year at the NIEHS since inception. During the past year, Dr. Fessler was granted tenure in the NIH intramural research program. Publications since the last annual report include: 1) a collaborative report showing that the localization inside cells of the immunity related GTPases Irgm1 is controlled by its modification with the fatty acid palmitate (Henry et al., PLoS One. 2014 Apr 21;9(4):e95021). 2) a senior-author report showing the the tumor suppressor p53 and the transcription factor NF-kB cooperate to induce pro-inflammatory cytokines in primary human macrophages (Lowe et al., Cancer Res. 2014 Apr 15;74(8):2182-92). 3) a co-first author report showing that apolipoprotein E regulates the development of acute lung injury in a mouse model (Yamashita et al., Respiration. 2014;87(5):416-27). 4) a senior author report showing that the epsilon 4 allele of the human gene APOE (ie, APOE4) associates with heightened inflammatory responses in humans (Gale et al., J Allergy Clin Immunol. 2014 Jul;134(1):127-134.e9). 5) a collaborative report showing that the cholesterol transporter ABCG1 controls generation of extracellular cholesterol domains on macrophages, a finding relevant to cholesterol transport(Freeman et al., J Lipid Res. 2014 Jan;55(1):115-27). 6) a collaborative report on the acute and chronic effects of low-density lipoprotein on neutrophil function (Palvinskaya T et al., Pulm Pharmacol Ther 2013). 7) a first-author report that serum cholesterol has a relationship to indices of erythrocytes (eg, hematocrit) and platelets (eg, platelet count) among U.S. citizens (Fessler et al., J Lipid Res. 2013 Nov;54(11):3177-88). 8) a senior author report that scavenger receptor B-I regulates pulmonary host defense against infection (Gowdy et al., Mucosal Immunology 2014, in press). Additional accomplishments since our last report include invited talks by Dr. Fessler at the NIH Cytokine Interest Group Lipid Mediators in Inflammation Meeting (2014), the 142nd meeting of the National Advisory Environmental Health Sciences Council, and the Rx for Science Literacy Workshop of the NC Assoc. for Biomedical Research. Dr. Fessler also served as a poster session facilitator at the 2014 American Thoracic Society International Conference. Several of Dr. Fesslers trainees also received awards/recognition since the last report, including postdoctoral fellow Kymberly Gowdy (Second Place, Postdoctoral Fellow Poster Competition, Visiting Pulmonary Scholars Symposium, UNC Friday Center; oral presentation at 2014 ATS International Conference), and graduate student Michael Henderson (Best Poster Presentation from Graduate Student, UNC Toxicology Curriculum).