MRI-Guided Cardiac Focused Ultrasound Ablation

该项目的长期目标是开发一种非侵入性治疗肥厚性梗阻性食管炎的方法。 心肌病（HOCM）。聚焦超声（FUS）是一种很有前途的无创性热疗技术， 消融术这里提出的努力解决了使用聚焦超声的主要技术挑战 治疗在心中。具体而言，我们的目标是：1）评估磁共振（MR）引导的疗效 相控阵聚焦超声（FUS）治疗，用于非侵入性消融心肌，包括 在存在胸腔和肺的射束路径阻塞的情况下靶向心脏的策略， 使消融与心律同步，2）开发强大的实时靶向和温度 使用磁共振成像在心脏中进行监测，以及3）进行初始测试和评估， 系统 我的近期职业目标是开发必要的FUS消融和MR成像策略， FUS消融是治疗HOCM的一种无创性替代方法。在学习阶段，我 参加了放射科、心脏科和 斯坦福大学的电子工程。我能够理解心脏生理学， 除了进一步发展我在心脏磁共振方面的专业知识外， 共振成像和MR测温。我已经接受了加州旧金山大学的教职 弗朗西斯科在放射学和生物医学成像部门，我可以独立研究， 开发具有潜在临床应用价值的MR引导聚焦超声技术。我的长期职业生涯 我们的目标是继续为MR引导聚焦超声治疗领域做出贡献，并使其成为 通过探索新的、侵入性较小的治疗方案，对患者护理产生根本性影响。

The long-term goal of this project is to develop a noninvasive treatment for hypertrophic obstructive cardiomyopathy (HOCM). Focused ultrasound (FUS) is a promising technique for noninvasive thermal ablation. The effort proposed here addresses the main technical challenges to using focused ultrasound therapy in the heart. Specifically, we aim to 1) evaluate the efficacy of magnetic resonance (MR) guided phased array focused ultrasound (FUS) therapy to non-invasively ablate the myocardium, including strategies to target the heart in the presence of beam path obstruction by ribcage and lungs and to synchronize the ablation to the rhythm of the heart, 2) develop robust real-time targeting and temperature monitoring in the heart using magnetic resonance imaging, and 3) perform initial testing and evaluation ofthe system. My immediate career goal is to develop the necessary FUS ablation and MR imaging strategies to make MRguided FUS ablation a noninvasive alternative for the treatment of HOCM. During the mentored phase, I have participated in interdisciplinary collaboration between the Departments of Radiology, Cardiology, and Electrical Engineering at Stanford University. I was able to gain an understanding of cardiac physiology and ofthe principles of therapeutic ultrasound, in addition to further developing my expertise in cardiac magnetic resonance imaging and MR-thermometry. I have accepted a faculty position at University of California San Francisco in the Department of Radiology and Biomedical Imaging where I can independently research and develop MR-guided focused ultrasound techniques with potential clinical applications. My long-term career goal is to continually contribute to the field of MR-guided focused ultrasound therapy and to make a fundamental impact on patient care_by exploring new, less invasive treatment options.