KAATSU Training to Enhance Physical Function of Older Adults with Osteoarthritis

描述（由申请人提供）：随着美国人口老龄化和老年人骨关节炎（OA）患病率的上升，预防OA相关残疾是一项重要的公共卫生优先事项。因此，需要有效的干预措施来管理疼痛和维持OA老年人的身体功能。由于骨骼肌无力是OA患者疼痛进展和功能下降的主要促成因素，因此最佳干预措施是能够改善骨骼肌强度的干预措施。高强度抗阻运动是提高肌肉力量的最佳方法;然而，高压缩负荷通常会在OA患者中引起显著的关节疼痛。因此，目前的建议包括进行低强度或中等强度的体育锻炼-尽管这些训练模式对于增强肌肉力量来说是次优的。本申请建议进行一项试点研究，以调查一种创新的训练模式的潜力，这种训练模式有可能在利用低强度负荷的同时刺激骨骼肌力量的改善。这种模式，被称为KAATSU训练，包括进行低强度运动，同时外部施加的压力温和地限制了血液流向活动的骨骼肌。本申请的首要目标是评估慢性KAATSU训练用于改善年龄> 60岁的具有症状性膝OA和轻度至中度身体限制的人的骨骼肌强度和身体功能的功效和可行性。总共将招募60名参与者参加这项为期三个月的干预研究。参与者将被随机分配到两种干预条件之一：（1）标准运动干预，包括基于中心的中等强度阻力训练，或（2）与整体工作量相匹配的KAATSU训练计划。这项研究将提供新的信息有关的治疗潜力的Kaatsu训练，以提高力量和功能，以及减轻疼痛，这些人。该研究还将通过评估参与者的安全性、不适感和意愿，提供有关该范式长期临床可行性的关键信息， 持续参与KATSU培训计划。

DESCRIPTION (provided by applicant): As the U.S. population ages and the prevalence of osteoarthritis (OA) among older adults rises, the prevention of OA-associated disability is an important public health priority. Accordingly, efficacious interventions are needed to manage pain and maintain physical function among older adults with OA. Because skeletal muscle weakness is a primary contributory factor to the progression of pain and functional decline among persons with OA, optimal interventions are those capable of improving skeletal muscle strength. High-intensity resistance exercise is the best-known method of improving muscle strength; however high-compressive loads typically induce significant joint pain among persons with OA. Accordingly, current recommendations include the performance of low- or moderate-intensity physical exercise - despite the fact that these training paradigms are sub-optimal for enhancing muscle strength. This application proposes conduct a pilot study to investigate the potential of an innovative training paradigm with potential to stimulate improvements in skeletal muscle strength while utilizing low-intensity loads. This paradigm, known as KAATSU training, involves performing low-intensity exercise while externally-applied compression mildly restricts blood flow to the active skeletal muscle. The overarching objective of the present application is to evaluate the efficacy and feasibility of chronic KAATSU training for the improvement of skeletal muscle strength and physical function among persons aged > 60 years with symptomatic knee OA and mild to moderate physical limitations. A total of 60 participants will be recruited to participate in this three month intervention study. Participants will be randomly assigned to one of two intervention conditions: (1) a standard exercise intervention consisting of center-based, moderate- intensity resistance training, or (2) a KAATSU training program matched for overall workload. This study will provide novel information regarding the therapeutic potential of KAATSU training for improving strength and function as well as attenuating pain among these individuals. The study will also provide critical information regarding the long-term, clinical viability of the paradigm by evaluating participant safety, discomfort, and willingness to continually engage in the KAATSU training program.