FASEB SRC on Protein Folding in the Cell

描述(由申请者提供)：我们请求对2014、2016和2018年FASEB科学会议的部分支持，会议的主题是“细胞中的蛋白质折叠”。2014年会议将于2014年7月20日至27日在佛蒙特州萨克斯顿的S河畔举行。这次非常成功的会议是独一无二的，将细胞生物学家、遗传学家、生物物理学家、生物化学家和数学建模人员聚集在一起，解决蛋白质折叠和错误折叠的复杂问题及其对人类疾病的影响。这次会议对该领域的发展至关重要，无论怎么说都不为过。这一主题的最新进展是爆炸性的，与蛋白质折叠和组装缺陷有关的疾病数量也是如此。因此，贯穿整个会议的一个共同主线是蛋白质折叠/错误折叠的生物物理后果与人类疾病之间的联系。与会者依赖于各种各样的新兴技术，包括来自基因组学、计算生物学、生物物理学、合成生物学和化学的技术，因此将强调强调新技术进步的演讲。在过去会议成功模式的基础上，具体会议将重点介绍蛋白质折叠途径、分子伴侣的作用机制、导致蛋白质聚集的途径、蛋白质折叠网络和网络的演变、蛋白质降解途径、细胞器和细胞质应激反应，以及蛋白质折叠缺陷对生物体健康、衰老和发育的影响。2014年，重点将放在新出现的用药物“纠正”蛋白质错误折叠的策略上。本次会议还包括三个完整的中午海报会议，作为更详细的科学讨论的纽带，并将促进成熟的研究人员、学生和其他早期职业科学家和行业代表之间的互动。职业发展机会包括午餐时间的“主题桌”，由受邀的演讲者领衔，专注于与职业发展相关的单一主题(撰写奖学金建议书、工业研究、文科学院的教师职位，以及平衡工作和家庭)。这次会议坚定地致力于增加科学工作者的多样性，这反映在 特邀演讲者。此外，三分之一的发言者将从提交的摘要中选出，以最大限度地扩大参与者和主题的多样性。佛蒙特州萨克斯顿S河畔佛蒙特州学院周围的小镇环境为与会者提供了便利的资源，以减少参与的障碍，包括中等价位的B&B和儿童保育选择。2016年和2018年会议的计划将建立在会议的既定优势和独特利基基础上，将不同的科学家和研究方法聚集在一起，并突出该领域的新发展和新兴发展。

DESCRIPTION (provided by applicant): We request partial support for the 2014, 2016 and 2018 FASEB Science Conference on "Protein Folding in the Cell". The 2014 meeting will be held July 20-27, 2014 in Saxton"s River, VT. This extraordinarily successful meeting is unique in bringing together cell biologists, geneticists, biophysicists, biochemists, and mathematical modelers to tackle the complex problems of protein folding and misfolding and their implications for human disease. The extent to which this meeting is central to the development of the field cannot be overstated. Recent progress in this topic has been explosive, as has the number of diseases linked to defects in protein folding and assembly. Thus, a common thread that runs through the conference are the associations between the biophysical consequences of protein folding/misfolding and human disease. Meeting attendees rely on diverse and emerging techniques, including those drawn from genomics, computational biology, biophysics, synthetic biology, and chemistry, and hence presentations highlighting new technological advances will be emphasized. Building upon the successful format that has shaped past meetings, specific sessions will highlight the protein folding pathway, the mechanism of action of molecular chaperones, pathways that lead to protein aggregation, protein folding networks and the evolution of networks, protein degradation pathways, organelle and cytoplasmic stress responses, and the consequences of defects in protein folding on organismal health, ageing, and development. For 2014, specific emphasis will be placed on emerging strategies to pharmacologically "correct" protein misfolding. This meeting also features three integral mid-day poster sessions, which serve as a nexus for more detailed scientific discussions and will facilitate interactions amongst established investigators, students and other early- career scientists and industry representatives. Career development opportunities include lunchtime "topic tables", led by invited speakers and that focus on a single topic relevant to career advancement (Writing Fellowship Proposals, Research in Industry, Faculty Positions at Liberal Arts Colleges, and Balancing Work and Family). This meeting has a strong commitment to increasing the diversity of the scientific workforce, and this is reflected in the diversity of the invited speakers. In addition, one-third of all speakers will be selected from submitted abstracts in order to maximize participant and topical diversity. The small-town environment surrounding Vermont Academy in Saxton"s River VT provides ready access to resources to reduce barriers to participation by attendees accompanied by family members, including moderately priced B&Bs and childcare options. Programs for the 2016 and 2018 conferences will build upon the established strengths and unique niche of the meeting to draw together diverse scientists and research approaches, and highlight new and emerging developments in the field.