Enhanced Surveillance for New Vaccine Preventable Disease

项目摘要/摘要 该合作协议的目的是支持一个网站网络，这些网站提供 监测和收集关于新疫苗使用、新疫苗的影响和 即将到来的疫苗和其他免疫预防、新的疫苗政策和政策 正在考虑通过加强住院和急诊科(ED) 监测、应用流行病学研究和调查员发起的调查。 这一新的疫苗监测网络(NVSN)将面向2020年的健康人 免疫和传染病的优先领域，具体地说，减少或 消除疫苗可预防的疾病并评估#年疫苗接种覆盖率 普遍推荐的疫苗。 NVSN计划的目的是利用基于人口的站点网络来 除了提供框架外，还对急性胃肠炎进行积极监测 在其中研究疫苗的其他重要相关问题。 主要焦点将是描述轮状病毒感染的负担和流行病学。 导致15天至11岁儿童住院和急诊室就诊 积极监测急性胃肠炎。急性胃肠炎的主动监测 将在两个环境(医院和急诊室)进行，以确定 急性胃肠炎和轮状病毒在这些环境中的每一种情况，并检查 时间(许可前和许可后)。11岁的儿童在医院住院或接受护理 有年龄症状的ED将被筛查，如果他们符合资格，邀请他们参加 标准，并同意这项研究。人口统计和临床数据将收集在 所有登记在册的儿童。将收集一份粪便样本并进行轮状病毒检测。数据将 被分析以估计基于人群的轮状病毒住院率和急诊率，以 儿童急性胃肠炎的临床和流行病学特征 由于轮状病毒，利用通过本研究获得的轮状病毒病例进行应用 轮状病毒疫苗效果和成本的流行病学评估 轮状病毒病和其他病原体的负担，如使用诺沃克病毒 通过这一监测系统获得的具有良好特征的数据和标本。

PROJECT SUMMARY/ABSTRACT The purpose of this cooperative agreement is to support a network of sites that provide surveillance and data collection on new vaccine use, the impact of the new vaccines and upcoming vaccines and other immunoprophylaxis, new vaccine policies and policies under consideration, through enhanced inpatient and emergency department (ED) surveillance, applied epidemiologic research, and investigator-initiated investigations. This New Vaccine Surveillance Network (NVSN) will address the Healthy People 2020 priority area for immunization and infectious diseases, specifically, the reduction or elimination of vaccine preventable diseases and evaluating vaccination coverage for universally recommended vaccines. The intent of the NVSN program is to utilize a network of population-based sites to conduct active surveillance for acute gastroenteritis in addition to providing a framework in which to study other important vaccine related questions. The major focus will be to describe the burden and epidemiology of rotavirus infection resulting in hospitalization and ED visits between 15 days and 11 years of age using active surveillance for acute gastroenteritis. Active surveillance for acute gastroenteritis will be conducted in 2 settings (hospital and ED) to determine the disease burden of acute gastroenteritis and rotavirus in each of these settings and to examine trends over time (pre- and post-licensure). Children <11 years of age hospitalized or cared for in the ED with symptoms of AGE will be screened, invited to participate if they meet eligibility criteria and consented for the study. Demographic and clinical data will be collected on all enrolled children. A stool specimen will be collected and tested for rotavirus. Data will be analyzed to estimate population-based rotavirus hospitalization and ED visit rates, to characterize the clinical and epidemiologic factors of children with acute gastroenteritis due to rotavirus, to utilize rotavirus cases obtained through this study to conduct applied epidemiologic evaluations of the effectiveness of rotavirus vaccines and costs of rotavirus disease and to examine the burden of other pathogens such as norovirus using the well characterized data and specimens obtained through this surveillance system.