Biobehavioral Influences on Cancer: Perspectives from Psychoneuroimmunology

描述(由申请人提供)：这份K05申请从心理神经免疫学的角度阐述了生物行为对癌症的影响。炎症是大多数癌症的风险因素，在过去十年里一直是基科尔特-格拉泽博士的主要免疫学关注点。她目前资助的项目解决了炎症在癌症相关疲劳中的作用，以及关于高饱和脂肪饮食后的餐后炎症如何可能成为慢性炎症反应的驱动因素的问题。K05将允许PI 1)在这项跨学科研究中促进新的和初级的调查人员的职业发展。K05还将通过提供必要的保护时间使她的研究保持在前沿，2)获得关于人类营养和新陈代谢的正式和非正式培训，并将允许她3)使用这些新知识来扩展和完善她的翻译工作，解决与炎症、肥胖和癌症相关的行为和营养之间的交叉。她的实验室提供了出色的培训环境。作为基础科学和临床科学的桥梁，她目前资助的工作利用了不同的方法，包括纵向观察研究、随机对照试验和复杂的实验室范例。正式合作者包括免疫学家、病毒学家、内分泌学家、肿瘤学家、营养/饮食研究人员、心理学家和生物统计学家。这种对不同范式和学科的广泛接触为学员提供了一个特殊的教育机会。她以前的研究生和博士后研究员非常成功地获得了优秀的教职并获得了NIH的资助。为了促进新的和初级的研究人员在与癌症生存相关的生物行为问题上的职业发展，这是首要的培训目标，她将与受训人员合作，发展他们对相关文献和方法问题的知识，教他们批判性地分析研究并确定优势和劣势，指导他们提高科学写作的技能和生产力的策略，并模拟和促进他们与关键的跨学科合作者的互动。世界卫生组织医学研究所成员 作为美国国家科学院院士，Kiecolt-Gaser博士是一位久负盛名的资深研究员，他展示了持续、高水平的研究和指导生产力。这一K05将减轻PI的大量行政责任，并使她有可能投入25%的总努力来指导年轻科学家，他们可以从心理神经免疫学的角度为我们理解癌症生存中的生物行为影响做出显著贡献，并将额外的研究时间投入到与影响癌症风险和临床结果的行为、内分泌和免疫系统相互作用相关的更新研究工作中。

DESCRIPTION (provided by applicant): This K05 application addresses biobehavioral influences on cancer from a psychoneuroimmunological perspective. Inflammation, a risk factor for most cancers, has been Dr. Kiecolt-Glaser's primary immunological focus during the last decade. Her current funded projects address the role of inflammation in cancer-related fatigue, as well as questions about how postprandial inflammation following meals high in saturated fat may act as a driver for chronic inflammatory responses. The K05 will allow the PI 1) to promote the career development of new and junior investigators in this transdisciplinary research. The K05 will also keep her research at the cutting edge by providing the protected time necessary 2) to obtain formal and informal training in human nutrition and metabolism, and will allow her 3) to use this new knowledge to expand and refine her translational work that addresses the intersection between behavior and nutrition relevant to inflammation, obesity, and cancer. Her laboratory provides an outstanding training environment. Bridging basic and clinical science, her current funded work utilizes diverse methodologies including longitudinal observational studies, randomized controlled trials, and elaborate laboratory paradigms. Formal collaborators include immunologists, virologists, endocrinologists, oncologists, nutritional/dietary researchers, psychologists, and biostatisticians. This broad exposure to diverse paradigms and disciplines provides an exceptional educational opportunity for mentees. Her former graduate students and postdoctoral fellows have been extremely successful in securing excellent faculty positions and obtaining NIH funding. To promote the career development of new and junior investigators in biobehavioral issues related to cancer survivorship, the overarching training goal, she will work with trainees to develop their knowledge of relevant literature and methodological issues, teach them to critically analyze research and identify strengths and weaknesses, tutor them in strategies for enhanced skill and productivity in scientific writing, and model and promote their interactions with key interdisciplinary collaborators. A member of the Institute of Medicine of the National Academy of Sciences, Dr. Kiecolt-Glaser is a senior and well-established researcher who has demonstrated a sustained, high level of research and mentoring productivity. This K05 will relieve the PI of substantial administrative responsibilities and make it possible to commit 25% of her total effort to mentoring younger scientists who can make notable contributions to our understanding of biobehavioral influences in cancer survivorship from a psychoneuroimmunological perspective, as well as additional research time to newer research efforts related to nutritional influences on behavioral, endocrine, and immune system interactions that affect cancer risk and clinical outcomes.