University of Michigan Regional Coordinating Stroke Center

描述(由申请人提供)：密歇根大学区域卒中协调中心(UM RCC)的目的是通过临床试验登记和实施以及在卒中研究方面培训初级研究人员，全面参与NINDS卒中试验网络。UM RCC包括位于地理紧凑地区的分支机构，UM与该地区有合作的历史，并提供接触到大量和多样化的中风患者群体的机会。申请者已经组建了一个专门的多学科研究团队，他们在中风临床试验方面经验丰富，渴望在网络试验中合作，并为所有符合条件的患者提供登记。其中还包括世界级的专家 在中风基础科学中，谁能在UM RCC和整个网络中为领导和培训做出贡献。鉴于UM RCC研究人员在卒中相关临床试验方面的专业知识，UM RCC还将提出在该网络中进行试验的建议。密歇根大学已经是NINDS资助的神经急症治疗试验(NETT)网络的全国临床协调中心(PI：BARSAN)的所在地，因此在网络内临床试验的设计和实施方面拥有经验。此外，通过NETT，UM拥有执行主临床试验协议和进行紧急研究需要知情同意的例外情况的试验的经验。对于在UM RCC内成功进行临床试验同样重要的是，UM卒中计划在培养卒中临床研究人员方面拥有经过证明的记录，因为这是其奖学金计划的主要使命。UM拥有独特的资源，通过其国家认可的公共卫生学院和罗伯特·伍德·约翰逊基金会临床学者计划，提供临床研究的正式教学培训。密歇根大学RCC的受训者也将从在中风临床试验和临床中风研究方面拥有丰富专业知识的多学科教员的指导中受益匪浅。

DESCRIPTION (provided by applicant): The purpose of a University of Michigan Regional Coordinating Stroke Center (UM RCC) is to participate fully in the NINDS Stroke Trials Network through clinical trial enrollment and implementation, and the training of junior investigators in stroke research. The UM RCC includes affiliate spokes in a geographically compact region with which UM has a history of collaboration, and provides access to a large and diverse stroke patient population. The applicants have assembled a dedicated multidisciplinary team of investigators who are experienced in stroke clinical trials and anxious to work collaboratively on Network trials and offer enrollment to all eligible patients. Included are also world-class experts in stroke basic science who can contribute to the leadership and training within a UM RCC and the overall network. Given the expertise of the UM RCC investigators in stroke-related clinical trials, a UM RCC would also anticipate proposing trials to be conducted in the Network. The University of Michigan is already home to the NINDS-funded Neurological Emergencies Treatment Trials (NETT) network's national Clinical Coordinating Center (PI: Barsan) and thus has experience with the design and conduct of clinical trials within networks. Furthermore, through the NETT, UM has experience executing master clinical trial agreements and conducting trials that require exception from informed consent for emergency research. Equally as important to the successful conduct of clinical trials within a UM RCC, the UM Stroke Program has a proven track record for developing clinical researchers in stroke, as this is the primary mission of its fellowship program. Unique resources are available at UM for formal didactic training in clinical research through its nationally recognized School of Public Health and its Robert Wood Johnson Foundation Clinical Scholars Program. Trainees within a UM RCC would also benefit tremendously from the mentorship of a multidisciplinary faculty with significant expertise in stroke clinical trials and clinical stroke research.