Genomics

在遗传学和基因组学研究的历史上，从来没有比今天更令人兴奋的时刻。基因组技术每天都在进步，以惊人的速度开发出更好、更快、更便宜的方法。因此，基因组的发现也在以前所未有的速度推进。NORC基因组学核心（GC），由博士领导。Molly Bray和Jose Fernandez，通过为NORC研究人员提供肥胖和营养的遗传和基因组研究的先进方法，为研究遗传变异和基因功能对肥胖结果的影响提供了批判性的能力。自2000年成立以来，Genomics Core（前身为Genetics Core）一直为研究样本的制备和存储以及DNA序列的表征提供服务。在过去的资助周期中，NORC基因组学核心已经支持了32名研究人员，25个联邦资助项目和9个试点项目，并发表了55篇论文。通过UAB最近获得的新的合作和扩展的基因组学资源（如下所述），我们现在有能力为我们的成员提供更广泛的基因组学服务，包括全基因组基因分型，基因表达和甲基化阵列，低通量和高通量定制基因分型和基因表达，以及标准和下一代测序（NGS）。除了我们的技术能力，基因组学核心董事，博士。Bray和Fernandez不仅可以提供基因组测定和分析选择方面的指导，而且还是肥胖遗传学、干预反应表型和遗传混合方面的专家。这种专业知识通过提供方法和内容专业知识来增强基因组学核心的价值。

Never has there been a more exciting time in the history of genetics and genomics research than today. Genomic technologies are advancing on a daily basis, with better, faster, and cheaper methodologies being developed at an astounding rate. As such, genomic discovery is also advancing at an unprecedented pace. The NORC Genomics Core (GC), led by Drs. Molly Bray and Jose Fernandez, provides the critic^al capacity to examine the effects of genetic variation and gene function on obesity outcomes by making available advanced methodologies for genetic and genomic studies of obesity and nutrition for NORC investigators. Since its inception in 2000, the Genomics Core (formerly, the Genetics Core) has provided services for preparation and banking of study samples and the characterization of DNA sequence. In the past funding cycle, the NORC Genomics Core has supported 32 investigators, 25 federally funded projects, and nine pilot projects, resulting in 55 publications. Through new collaborations and expanded genomics resources recently acquired by UAB (described below), we now have the capacity to provide a wider range of genomics services to our member base, including whole genome genotyping, gene expression, and methylation arrays, low and high throughput custom genotyping and gene expression, and standard and next generation sequencing (NGS). Beyond our technological capabilities, the Genomics Core directors, Drs. Bray and Fernandez, can provide not only guidance on selection of genomic assays and analyses but are also experts in obesity genetics, intervention response phenotypes, and genetic admixture. This specialized knowledge enhances the Genomics Core's value by providing both methodologic and content expertise.