Using Metabolomics to Define the Behavioral Phenomics of Energy Balance and Exercise Response

使用代谢组学定义能量平衡和运动反应的行为表型组学

• 批准号: 10019523
• 负责人: Molly Bray
• 金额: $ 65.66万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-18 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10019523
• 关键词: Adherence; Aerobic Exercise; Attitude; Basal metabolic rate; Behavior; Behavioral; Behavioral Model; Biological; Biology; Body Weight; Body Weight decreased; Body fat; Citrus; Cohort Studies; Complex; DNA; Data; Development; Diet; Dietary Factors; Dietary Practices; Dietary intake; Eating; Eating Behavior; Educational Intervention; Energy Intake; Environment; Equation; Ethnic group; Etiology; Exercise; Family Study; Fatty acid glycerol esters; Fiber; Fishes; Food; Food Energy; Food Preferences; Genetic; Genetic Variation; Genetic study; Genomics; Genotype; Goals; Health behavior; Heritability; Heterogeneity; Homeostasis; Individual; Intervention; Light; Measures; Meat; Metabolic Pathway; Methodology; Nutrient; Nutritional Study; Obesity; Participant; Pathway interactions; Patient Self-Report; Pattern; Performance; Phenotype; Physical activity; Physiological; Plasma; Play; Prevention program; Preventive Intervention; Protocols documentation; Psychosocial Factor; Public Health; RNA; Reporting; Research; Resources; Risk; Role; Sampling; Side; Statistical Methods; Time; Twin Studies; Validation; Weight; Weight Gain; biobank; density; design; diet and exercise; effective intervention; energy balance; exercise intensity; exercise intervention; exercise training; experience; food consumption; food quality; genetic variant; high dimensionality; increased appetite; insight; metabolic profile; metabolomics; multiple data sources; obesity treatment; phenomics; prevent; psychologic; psychosocial; racial and ethnic; response; trait; weight loss intervention

ABSTRACT Current treatments for obesity have been largely unsuccessful in maintaining long-term weight loss, demonstrating the tremendous need for new insight into mechanisms that may stably alter body mass and composition. There is significant heterogeneity in response to intervention/prevention programs designed to reduce the risk and occurrence of obesity, suggesting that some individuals may be responsive to a given intervention while others are not. In this project, we will integrate dietary, psychosocial/behavioral, exercise performance, and metabolomics data, within the context of a well-controlled exercise intervention, to characterize the behavioral phenomics of energy balance (BPEB). BPEB is a high dimensional representation of the complex interplay between behavioral components of energy balance characterized at multiple levels, from dietary intake to exercise and physical activity to the psychosocial drivers of both behaviors. In addition, we will determine how exercise training influences change in BPEB, and we will use high density genotype and metabolomic data to derive the genetic and metabolic pathways that interact with BPEB to regulate and influence changes in body mass/composition following a high intensity aerobic exercise intervention. In this proposal, we will leverage the existing resources of the Training Interventions and Genetics of Exercise Response (TIGER) Study and the UK Biobank. The TIGER Study is one of the largest studies of the genetics of exercise response in which participants have undergone a rigorous and empirically-documented aerobic exercise training protocol. The TIGER Study cohort consists of 3,665 participants from multiple racial/ethnic groups, with an average BMI of 26.26.3 kg/m2 . A comprehensive battery of behavioral data, phenotypes, genotypes, and stored samples (DNA, RNA, and plasma) are available to this proposed study, and more than 120,000 recorded exercise sessions with documented duration, intensity, and mode have been recorded in the TIGER Study. Participants also reported psychological parameters related to eating behavior and physical activity. Importantly, a substantial proportion of TIGER participants experienced significant weight loss throughout the course of the study, despite the fact that TIGER was not a weight loss trial, providing a unique opportunity to study spontaneous changes in dietary and psychosocial factors in the context of exercise. We will use the resources of the UK Biobank, which has more than 500,000 participants and a complementary array of phenotype and behavior data, for validation of our findings. Our goal is to reveal new pathways that regulate, influence, and/or interact with diet and exercise behavior to ultimately determine body mass and adiposity.

抽象的 目前的肥胖治疗在维持长期体重减轻方面基本上不成功， 证明了对可能稳定改变体重和的机制的新见解的巨大需求 作品。对旨在实现以下目的的干预/预防计划的反应存在显着的异质性： 降低肥胖的风险和发生率，表明某些人可能对特定的 干预，而其他人则不干预。在这个项目中，我们将整合饮食、心理社会/行为、运动 在良好控制的运动干预背景下，表现和代谢组学数据可以表征 能量平衡行为表组学（BPEB）。 BPEB 是复杂的高维表示 能量平衡的行为成分之间的相互作用在多个层面上表现出来，来自饮食摄入 锻炼和体育活动是这两种行为的心理社会驱动因素。此外，我们将确定如何 运动训练影响BPEB的变化，我们将使用高密度基因型和代谢组数据来 推导与BPEB相互作用的遗传和代谢途径来调节和影响身体的变化 高强度有氧运动干预后的质量/成分。在本提案中，我们将利用 训练干预和运动反应遗传学 (TIGER) 研究和英国的现有资源 生物样本库。 TIGER 研究是关于运动反应遗传学的最大研究之一，其中参与者 接受过严格且有经验记录的有氧运动训练方案。老虎研究 该队列由来自多个种族/民族的 3,665 名参与者组成，平均 BMI 为 26.2±6.3 kg/m2。 行为数据、表型、基因型和存储样本（DNA、RNA 和 血浆）可用于这项拟议的研究，并且超过 120,000 次记录的运动课程 TIGER 研究中已记录了持续时间、强度和模式。与会者还报告了 与饮食行为和体力活动相关的心理参数。重要的是，相当大的比例 TIGER 参与者在整个研究过程中经历了显着的体重减轻，尽管事实上 TIGER 不是一项减肥试验，它提供了一个独特的机会来研究饮食的自发变化 以及运动背景下的心理社会因素。我们将利用英国生物银行的资源，该银行拥有 超过 500,000 名参与者以及一系列互补的表型和行为数据，用于验证我们的 发现。我们的目标是揭示调节、影响和/或与饮食和运动相互作用的新途径 最终决定体重和肥胖的行为。