Cancer Survivorship: Decreasing the Risk of Colon Cancer Mortality

描述(由申请者提供)：这是一个设立的研究员奖，表彰Polly Newcomb博士将30%的精力投入到结直肠癌存活期的培训和研究中。她是一位经验丰富的癌症预防研究员，在NIH资助方面有着长期而成功的记录。由于筛查和治疗的成功，癌症幸存者的人数正在迅速增长；今天，美国有1100多万人有癌症病史。在美国，结直肠癌是男性和女性癌症死亡的第二大原因。因此，确定提高结直肠癌患者生存率的方法是患者、临床医生和护理人员的高度优先事项。结肠癌是一种复杂的疾病，由多种环境和遗传因素共同作用引起；确诊后的长寿也必须反映这些共同影响。这一K05奖项的目标是确定可改变的和遗传的因素，这些因素将改善男性和女性结直肠癌治疗后的生活质量和延长生存期。癌症生存是一个具有挑战性的预防研究领域，具有分析和控制偏差的独特方法，使其成为初级研究人员培训和发展的一个特别重要的领域。在这一奖项的支持下，纽科姆博士将投入15%的精力指导新的癌症控制研究人员，并为结直肠癌存活率的关键研究提供基础。利用纽科姆博士担任西雅图PI的结肠癌家族登记处(C-CFR)，拟议的研究将侧重于生活方式因素，如体力活动和营养，结直肠癌患者可以在确诊后改变这些因素以延长寿命。在这些研究中，受训人员和初级教员还将考虑遗传学、病理特征、分子标记和治疗，以评估复发和寿命的预测因素，为结直肠癌患者的生物学和护理提供见解。这一奖项将是一个有价值的机制，以更好地了解可以提高存活率的因素，并在这样做的同时，培养癌症控制方面的熟练研究人员。

DESCRIPTION (provided by applicant): This is an Established Investigator award for Dr. Polly Newcomb to dedicate 30% effort to training and research in colorectal cancer survivorship. She is an experienced cancer prevention investigator with a long and successful record of NIH-funding. The population of cancer survivors is rapidly growing because of screening and treatment successes; today more than 11 million U.S. individuals have a history of cancer. Colorectal cancer is the second leading cause of cancer death among men and women combined in the United States. Therefore, identifying approaches to improve survival in colorectal cancer patients is a high priority for patients, clinicians, and caregivers. Colon cancer is a complex disease caused by the joint action of multiple factors both environmental and genetic; longevity after diagnosis too must reflect these joint effects. The goal of this K05 award is to identify modifiable and genetic factors, which will improve quality of life and extend survival after treatment for colorectal cancer in men and women. Cancer survivorship is a challenging area of prevention research with unique methods for analyses and controlling bias, making it a particularly important area for the training and development of junior investigators. With the support provided by this award, Dr. Newcomb will dedicate 15% effort to mentoring new cancer control researchers and provide the foundation for key investigations in colorectal cancer survivorship. Utilizing the Colon Cancer Family Registries (C-CFR), for which Dr. Newcomb is the Seattle PI, the proposed research will focus on lifestyle factors, such as physical activity and nutrition that colorectal cancer patients can alter to enhance longevity after diagnosis. In these studies, trainees and junior faculty will also take into account genetics, pathological characteristics, molecular markers, and treatment to assess predictors of recurrence and longevity, providing insights into the biology and care for colorectal cancer patients. This award will be a valuable mechanism to better understand the factors that can enhance survival, and in doing so, develop skilled researchers in cancer control.