Core A: PREVENT Program Administrative Core

PREVENT计划的总体目标是将一种候选杀微生物剂凝胶推进临床试验 含有griffithsin（GRFT），旨在防止HIV-1的直肠传播。主 管理核心（核心A）的职责是监督、指导和协调三个部门的活动 研究项目和三个科学核心，以确保这一目标得到有效实现， 可能，并符合监管和申办者要求。核心A的总体目标是 为预防计划的项目和核心提供科学支持，使其能够进入 预防临床试验。具体目标1是确保有效的预防计划领导， 指导委员会的协调努力。目标2是为有效的 整个GRFT预防计划的运作。目标3是提供集中的财政管理， 目标4是提供一个内部结构，供内部和外部审查， 科学进步。

The overall objective of the PREVENT Program is to advance into clinical trials a candidate microbicide gel containing griffithsin (GRFT) that is designed to prevent rectal transmission of HIV-1. The primary responsibility of the Administrative Core (Core A) is to monitor, direct, and coordinate activities of the three research projects and three scientific cores to ensure that this objective is achieved efficiently, as quickly as possible, and in compliance with regulatory and sponsor requirements. The overarching goal of Core A is to provide scientific support to the PREVENT program's projects and cores to enable progression into the PREVENT clinical trial. Specific Aim 1 is to ensure effective PREVENT Program leadership through coordinated efforts of a Steering Committee (SC). Aim 2 is to provide administrative support for the effective functioning of the entire GRFT PREVENT program. Aim 3 is to provide centralized fiscal management of projects and cores, and Aim 4 is to provide an internal structure for both internal and external review of scientific progress.