Ambulatory assessment of alcohol use, mood dysregulation, and alcohol craving

描述（由申请人提供）：过度饮酒对健康有许多负面影响，包括死亡风险较高。此外，2006年，如果考虑到生产力、健康和保健以及犯罪的综合损失，过量饮酒的经济成本估计为2235亿美元。尽管在过去的几十年里，技术取得了前所未有的进步，但对酒精使用障碍（以及更普遍的精神病理学）的特征和相关性的临床评估仍然主要依赖于传统的纸笔问卷和面对面的临床访谈。然而，这些久经考验的方法在许多方面受到限制，包括完全依赖患者的回顾性自我报告，临床访谈者的技能以及评估的人工设置（临床咨询室）。本研究拟使用一种创新的方法，门诊评估（AA），以描述和调查酒精使用和依赖相关的成瘾（特别是，线索反应/渴望），和情绪失调的精神科门诊患者的特点是临床显着的情绪失调问题（心境障碍，焦虑症，或边缘型人格障碍），而在他们的自然环境中。这种“真实世界”的方法可以揭示酒精依赖的原因和相关因素，并建议改进治疗方法。

DESCRIPTION (provided by applicant): Excessive alcohol use has many negative health consequences, including higher risk of mortality. In addition, in 2006, the estimated economic cost of excessive drinking was $223.5 billion when the combined costs of lost productivity, health and health care, and crime are considered61. Despite unparalleled advances in technology over the last several decades, the clinical assessment of features and correlates of alcohol use disorders (and psychopathology more generally), still primarily relies on traditional paper-and-pencil questionnaires and face-to- face clinical interviews. However, these tried-and-true methods are limited in a number of ways, including total reliance on patients' retrospective self-report, the skill of the clinical interviewer, and the artificial setting of the assessment (te clinic consulting room). The present study proposes to use an innovative methodology, ambulatory assessment (AA) to describe and investigate alcohol use and dependence-related symptomatology (specifically, cue- reactivity/craving), and emotional dysregulation among psychiatric outpatients with disorders characterized by clinical significant emotional dysregulation problems (mood disorders, anxiety disorders, or borderline personality disorder) while in their natural environment. This "real-world" approach can shed light on the causes and correlates of alcohol dependence, and suggest improvements in treatment approaches.