Administrative Core

行政核心主任：安吉拉·M·格罗南博恩博士将主要负责指导和激励拟议的PCHPI的研究和计划。在过去的30年里，格罗南博恩博士一直在指导研究小组，首先是在英国伦敦的MRC，然后是德国慕尼黑的马克斯·普朗克生物化学研究所，1988年至2006年在贝塞斯达的国家卫生研究院。她负责监督技术人员、学生、博士后和永久科学工作人员的工作。她将指导核心之间以及核心与研究项目(内部和外部)之间协作框架的执行。此外。格罗南博恩博士将出席NIGMS指定的网络咨询委员会的年度会议和年度科学会议。格罗南博恩博士将编制PCHPI协作计划的年度更新(由执行委员会指导)，并将这些更新提供给咨询委员会。此外，主任和中心协调员将承担确保中心所有方面顺利运作的主要责任。格罗南博恩博士将担任执行委员会主席。中心协调员：Teresa Brosenitsch博士将担任中心协调员。Brosenitsch博士自PCHPI成立以来一直是该中心的一部分，并将继续监督该中心的日常运营以及成员和合作者之间的沟通。在格罗南博恩博士的行政助理的帮助下。Brosenitsch博士将确保会议、电话会议和教育项目按计划进行，并将监督研讨会和研讨会实施的后勤工作，包括旅行安排。Brosenitsch博士还将协调所有教育和协作促进活动，包括协作发展计划的征集、申请和审查过程。Brosenitsch博士直接向GronenBorn博士报告，并将监督执行委员会指令和政策的执行和协调。她将成为执行委员会的成员。主任和中心协调员将每两周定期举行一次会议。Brosenitsch博士将与结构生物系的工作人员密切合作，包括一名行政助理、业务经理和IT人员，以开展核心的活动。执行委员会：执行委员会将由中心主任、中心协调员、每个核心主任和每个项目的负责人组成。它将按月开会，并将确定研究优先事项，就如何克服技术问题和瓶颈制定战略，分析中心进展和遵守项目时间表，监督PCHPI的财务，建立和实施教育和培训计划，监督PCHPI的网络服务器内容，并就如何促进合作制定战略。科学咨询委员会(SAB)：将在与NIGMS协商并经其批准后任命一个科学咨询委员会。SAB将有至少三名外部顾问，包括一名病毒学家和一名结构生物学家，由执行委员会通过提名和投票任命。SAB将每年举行会议，审查中心在实现里程碑方面的进展(如第1节，方法中概述的那样)，为定义新的结构目标提供方向，并讨论改进进展的战略。审计委员会的咨询意见将在与项目继续或停止有关的决定中发挥重要作用(见下文)。SAB将被要求在他们访问后一个月内提供他们的批评的书面摘要。这一批评和PCHPI的回应将提供给NIGMS计划官员。NIGMS项目官员将被邀请参加PCHPI SAB的所有会议。顾问：在PCHPI资助的头五年，PCHPI的联席主任Ronald Montelaro博士将担任行政事务顾问，应用他在艾滋病毒-L领域的丰富知识和经验，帮助确定研究和合作的优先事项。

The Administrative Core Director: Angela M. Gronenborn, PhD will have the primary responsibility for directing and exciting the research and programs of the proposed PCHPI. Dr. Gronenborn has directed research groups for the last 30 years, first at the MRC in London, UK, then at the Max-Planck-institute for Biochemistry in Munich, Germany, and, from 1988-2006, at the NIH in Bethesda. She has overseen the work of technical personnel, students, post-docs and permanent scientific staff. She will direct the implementation of the collaborative framework among the cores and between the cores and research projects (both in-house and external). In addition. Dr. Gronenborn will attend the annual meetings of the NIGMS appointed network advisory committee and the annual scientific meeting. Dr. Gronenborn will prepare annual updates to the PCHPI's plans for collaboration (guided by the Executive Committee) and provide these to the Advisory Committee. In addition, the Director along with the Center Coordinator will have the primary responsibility for ensuring that all aspects of the center function smoothly. Dr. Gronenborn will chair the Executive Committee. Center Coordinator: Teresa Brosenitsch, PhD will serve as the Center Coordinator. Dr. Brosenitsch has been a part of the PCHPI since its inception and will continue to oversee the day-to-day operation of the center and communication among members and collaborators. With help from Dr. Gronenborn's administrative assistant. Dr. Brosenitsch will ensure that meetings, teleconferences, and educational programs occur as outlined and will oversee the logistics for workshop and seminar implementation, including travel arrangements. Dr. Brosenitsch will also coordinate all educational and collaboration promotion activities, including the Collaboration Development Program solicitation, application, and review processes. Dr. Brosenitsch reports directly to Dr. Gronenborn and will oversee implementation and coordination of the directives and policies of the Executive Committee. She will be a member of the Executive Committee. The Director and the Center Coordinator will have regularly scheduled meetings on a bi-weekly basis. Dr. Brosenitsch will work closely with the staff of the Department of Structural Biology, including an administrative assistant, the business manager, and IT personnel, to carry out the activities of the core. Executive Committee: The Executive Committee will be composed of the Center Director, the Center Coordinator, each of the core directors, and the leaders of each of project. It will meet on a monthly schedule and will define research priorities, strategize as to how to overcome technical problems and bottlenecks, analyze center progress and adherence to project timelines, provide oversight of PCHPI finances, establish and implement educational and training programs, provide oversight of the PCHPIs' web server content, and strategize about how to promote collaboration. Scientific Advisory Board (SAB): A Scientific Advisory Board will be appointed in consultation with and subject to approval of the NIGMS. The SAB will have at least three external advisors, including a virologist and a structural biologist, to be appointed by the Executive Committee through nominations and voting. The SAB will meet annually to review the center's progress toward milestones (as outlined in the Section 1, Approach), provide direction for defining new structural targets, and discuss strategies to improve progress. The advice of the SAB will play an important role on decisions related to project continuation or cessation (see below). The SAB will be asked to provide a written summary of their critique within a month of their visit. This critique and the PCHPI's response will be provided to the NIGMS program official. The NIGMS program official will be invited to attend all meetings of the PCHPI SAB. Consultant: Dr. Ronald Montelaro, co-Director of the PCHPI during the first five years of PCHPI funding will serve as a consultant on administrative matters, applying his extensive knowledge and experience in the HIV-l field, to help set research and collaboration priorities.