Gene Wiki: expanding the ecosystem of community-intelligence resources

描述（由申请人提供）：该提案描述了基因Wiki的持续维护和发展，其目标是为每个人类基因创建一个持续更新，社区审查和协作编写的评论文章。基因维基是直接在维基百科中创建的，是一个非正式的10,646篇基因相关文章的集合。在第一个资助期，基因Wiki“信息框”与基因组社区的源数据库同步的基础设施被开发出来。接下来，评估和量化Gene Wiki文章中每个词的可信度的方法被开发并在一个名为WikiTrust的系统中实现。最后，简单的文本挖掘应用于Gene Wiki能够识别出数千个新的基因注释。在下一个项目期间，Gene Wiki准备取得进一步的进展。首先，基因维基的范围将扩大到包括疾病和药物的评论文章。通过这一倡议将创建或维护数千篇文章，特别强调罕见疾病。第二，一个专门的外展组件将确保编辑社区的发展。这一拓展工作将会吸引那些对特定基因感兴趣的专家，以及那些想要基于基因Wiki为课堂项目设计课程的各级课堂教师。第三，在维基数据环境下构建“集中式模式生物数据库”，作为微生物基因和基因组注释数据的信息交换所。第四，将创建一个全新的众包应用程序，利用与患者一致的个人群体和他们推进研究的愿望。这些人将是一个新的群体，将被应用于系统地注释生物医学文献的挑战。总之，基因维基是生物医学研究的一个有用工具。这项建议的成功完成将通过众包带来更有效的知识管理和传播。

DESCRIPTION (provided by applicant): This proposal describes the continued maintenance and development of the Gene Wiki, the goal of which is to create a continuously-updated, community-reviewed, and collaboratively-written review article for every human gene. The Gene Wiki was created directly within Wikipedia as an informal collection of 10,646 gene-specific articles. In the first funding period, the infrastructure to keep Gene Wiki "infoboxes" in sync wit the source databases in the genomics community was developed. Next, methods to assess and quantify the trustworthiness of each word of a Gene Wiki article were developed and implemented in a system called WikiTrust. And finally, simple text-mining applied to Gene Wiki was able to identify thousands of novel gene annotations. During the next project period, the Gene Wiki is poised to make further strides. First, the scope of the Gene Wiki will be expanded to also include review articles on diseases and drugs. Thousands of articles will either be created or maintained through this initiative with a particular emphasis on rare diseases. Second, a dedicated outreach component will ensure that the community of editors is poised to grow. This outreach effort will engage both faculty members who are experts on specific genes of interest, as well as classroom instructors at all levels who want to design curriculum based on the Gene Wiki for a class project. Third, a "Centralized Model Organism Database" will be constructed in the Wikidata environment, which will serve as a clearing house of microbial gene and genome annotation data. And fourth an entirely new crowdsourcing application will be created that taps into crowds of patient-aligned individuals and their desire to advance research. These individuals will be a novel crowd that will be applied to the challenge of systematically annotating the biomedical literature. In summary, the Gene Wiki is a useful tool for biomedical research. Successful completion of this proposal will result in more efficient knowledge management and dissemination through crowdsourcing.