Boston Biomedical Innovation Center

在从学术界的生物医学发现到临床应用的道路上，存在着众所周知的差距 心血管、肺、肺等领域的治疗、设备和诊断技术的商业化 血液学和睡眠障碍。这种鸿沟是支持概念验证的资金不足的结果。 或对早期开发至关重要的验证研究；没有足够的资源和 开发新技术所需的专业知识；以及学术界缺乏知识和经验 研究人员将新想法带到商业实现中。在合作机构中包括 此应用程序是构建基础设施所需的基本要素，支持和 保持发明从发现到开发的不间断、持久的流动 商业化。虽然这些机构有着非常成功的发展的明确记录 在许多生物医学技术中，这些商业成功中的大多数都是通过坚韧不拔的 而不是在承诺的体制机制的帮助下。我们提议 通过在#年建立地区波士顿加速创新中心来解决这些关键缺陷 心、肺、血液和睡眠障碍的治疗、设备和诊断(B-BIC或波士顿 生物医学创新中心)。该中心的主要目标是：1)开发一个完整的 基础设施将扩大心脏、肺、血液和血液等可商业化技术的宇宙 睡眠障碍；2)通过参与将这些机会置于适当的评估环境中 IT“)、征集(”Find It“)和选择(”Pick It“)策略；3)高效和有效地将那些被选中的人带到 开发过程的适当退出点；以及4)提供教育和指导 在学术界开发适当的创业技能所需的基础设施 创新者。通过实现这些目标，B-BLC将改变我们的学术环境的文化，如 以及公营部门和私营部门在促进成功发展方面的关系 心、肺、血液和睡眠障碍方面的技术战略，最终造福于患者和社会。

A well-recognized gap exists in the path from biomedical discovery in academia to clinical application and commercialization of therapeutic, device, and diagnostic technologies in cardiovascular, pulmonary, hematologic, and sleep disorders. This chasm is the result of inadequate funding for support of proof-of-concept or validation studies essential for early stage development; insufficient access to the resources and expertise needed to develop new technologies; and a lack of knowledge and experience among academic investigators in bringing new ideas to commercial realization. Within the partnering institutions included in this application, the essential elements exist with which to build the infrastructure needed to support and sustain the uninterrupted, durable flow of inventions from discovery through development and commercialization. While these institutions have a clear track record of remarkably successful development of many biomedical technologies, most of these commercial successes have been achieved by the tenacity of individual inventors rather than with the help of committed institutional mechanisms. We proposed to address these key shortcomings by establishing the regional Boston Center for Accelerated Innovation in Therapeutics, Devices, and Diagnostics for Heart, Lung, Blood, and Sleep Disorders (B-BIC, or the Boston Biomedical Innovation Center). The key objectives of this Center are to: 1) develop an integrated infrastructure that would expand the universe of commercializable technologies for heart, lung, blood, and sleep disorders; 2) place these opportunities in the proper evaluative context through an engagement ("seed it"), solicitation ("find it"), and selection ("pick it") strategy; 3) efficiently and effectively bring those selected to an appropriate exit point from the development process; and 4) provide the educational and mentoring infrastructure necessary for the development of the proper entrepreneurial skills among academic innovators. By achieving these goals, B-BlC would change the culture of our academic environment, as well as the relationship between the public and private sectors in facilitating successful development strategies for technologies in heart, lung, blood, and sleep disorders for the ultimate benefit of patients and society.