Training in Pharmacological Sciences

药理学培训

• 批准号: 10612401
• 负责人: DAVID E. GOLAN
• 金额: $ 41.34万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10612401
• 关键词: Science; Training; pharmacologic

Project Abstract: We seek eight training slots to support students during their first and/or second year of training in pharmacological sciences. The Therapeutics Graduate Program (TGP) recruits students from multiple Harvard PhD programs to build a diverse and inclusive community focused on therapeutic science, with a strong focus on professional skills development and career mentoring. The TGP provides rigorous training in the science of drug discovery, evaluation, and clinical use through a required core curriculum, paracurricular activities focused on professional skills development, and a signature required internship, where students spend 2–4 months in an industrial or regulatory science setting before the end of their 4th year. Recruitment: The TGP will recruit students and faculty from multiple HMS and Harvard programs, including Biological and Biomedical Sciences (BBS), Chemical Biology, and Systems Biology graduate programs at Harvard Medical School (HMS), Harvard University, and the HMS-affiliated teaching hospitals. Faculty will be evaluated for scientific relevance and mentoring skills, and openness to student-centric training experiences. Diversity/inclusion: We are committed to building a diverse, inclusive, and supportive training community. Intellectual diversity will benefit by recruitment from multiple PhD programs. We will boost social and ethnic diversity by emphasizing how the TGP prepares students for careers with direct societal impact and provides clear and direct career preparation through internships. Professional skills and career development: We involve industry professionals in teaching 1st year classes and co-organizing paracurricular activities focused on skills development. Our required internship experience provides trainees with hands-on exposure to industrial or regulatory science work environments, and provides strong networking opportunities. Internships also help mentors understand the benefit of our commitment to student-centric training. Scientific rigor and responsible conduct: These components are emphasized throughout the curriculum, and reinforced by mentorships where students are exposed to team-based science in a professional setting. Training benefit: There is a strong demand for PhD-level scientists who have been rigorously trained in the core concepts of drug discovery. Demographic trends are increasing the need for drug treatments, and there is optimism for treating the most feared diseases based on recent progress and emergence of new drug modalities such as antibodies and oligonucleotides. Many research schools and hospitals are building translational research centers, often in collaboration with local industry, and these need to recruit faculty and PhD-level staff. The pharma/biotech industry has exploded in Massachusetts in the last decade, and many PhD-level positions remain unfilled. TGP trainees will lead in this growing field.

项目摘要： 我们寻求八个培训名额，以支持学生在他们的第一年和/或第二年的培训， 药理学治疗学研究生项目（TGP）从多个哈佛招收学生 博士课程，以建立一个多元化和包容性的社区，专注于治疗科学，具有很强的重点 专业技能发展和职业指导。三峡工程提供严格的科学培训， 通过必要的核心课程，课外活动，药物发现，评估和临床使用 专注于专业技能的培养，并要求实习签名，学生花2-4 在第四年结束前，在工业或监管科学环境中工作数月。招聘：TGP 将从多个HMS和哈佛项目中招募学生和教师，包括生物学和生物医学 科学（BBS），化学生物学和系统生物学研究生课程在哈佛医学院 (HMS)、哈佛大学和HMS附属教学医院。教师将被评估为科学 相关性和指导技能，以及以学生为中心的培训经验的开放性。多样性/包容性：我们 致力于建立一个多元化，包容性和支持性的培训社区。知识多样性将 从多个博士课程的招聘中受益。我们将促进社会和种族多样性， 三峡工程如何为学生准备具有直接社会影响的职业生涯，并提供明确和直接的职业生涯 通过实习做准备。专业技能和职业发展：我们涉及行业 专业人士在教学第一年类和共同组织课外活动的重点是技能 发展我们所需的实习经验为学员提供了动手接触工业或 监管科学工作环境，并提供强大的网络机会。实习也有帮助 导师了解我们致力于以学生为中心的培训的好处。科学严谨和 负责任的行为：这些组成部分在整个课程中得到强调，并通过以下方式得到加强： 导师制，让学生在专业环境中接触基于团队的科学。培训益处： 对博士水平的科学家有强烈的需求，他们在以下核心概念方面接受过严格的培训： 药物发现人口趋势正在增加对药物治疗的需求， 根据最近的进展和新药物模式的出现，治疗最可怕的疾病， 抗体和寡核苷酸。许多研究型学校和医院正在建立转化研究 这些中心通常与当地行业合作，需要招聘教师和博士级工作人员。的 制药/生物技术行业在过去十年中在马萨诸塞州爆炸式增长，许多博士级职位 仍然没有填补。三峡工程学员将在这一不断发展的领域发挥领导作用。

项目成果

An in silico method to assess antibody fragment polyreactivity.

• DOI: 10.1038/s41467-022-35276-4
• 发表时间: 2022-12-07
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Harvey, Edward P.;Shin, Jung-Eun;Skiba, Meredith A.;Nemeth, Genevieve R.;Hurley, Joseph D.;Wellner, Alon;Shaw, Ada Y.;Miranda, Victor G.;Min, Joseph K.;Liu, Chang C.;Marks, Debora S.;Kruse, Andrew C.
• 通讯作者: Kruse, Andrew C.

Base Editor Scanning Reveals Activating Mutations of DNMT3A.

• DOI: 10.1021/acschembio.3c00257
• 发表时间: 2023-09-15
• 期刊: ACS CHEMICAL BIOLOGY
• 影响因子: 4
• 作者: Garcia, Emma M.;Lue, Nicholas Z.;Liang, Jessica K.;Lieberman, Whitney K.;Hwang, Derek D.;Woods, James C.;Liau, Brian B.
• 通讯作者: Liau, Brian B.