Nuclear Receptors in Liver Health and Disease

需要五年的资金，以进一步发展堪萨斯大学医学中心的生物医学研究卓越中心，重点是核受体及其在肝脏健康和疾病中的作用。五名有同样研究兴趣的有才华的新教员被选中，目的是帮助他们成为有资金支持的独立调查人员。一个由资深教员组成的内部咨询委员会和一个由杰出科学家组成的外部咨询委员会已经成立，以指导他们实现这一目标。该中心还将帮助提供基础设施和设备，以补充研究环境。最终，通过实现这些最初的目标，最终的长期目标是提交计划项目拨款申请。这项建议的一个重要特点是，为每个初级教员分配了两名共同导师，并制定了个人辅导计划和时间表。指导计划的主要特点包括由导师和国际咨询委员会对研究项目进行持续的批判性评估，与欧洲咨询委员会成员举行半年一次的会议，以及关于统计、手稿和赠款撰写以及教学的特别培训。分配到这个Cobre的前6名初级教员已经成功地竞争了独立的NIH R01类型的研究支持。对现在的初级教员也有同样的期望。一旦现有的初级教员得到外部资助，他们将在财政上轮换拨款，为增加新的初级教员腾出空间。该提案的另一个重要特点是维持4个研究中心，为中心的教职员工提供额外的研究支持。这些核心包括行政核心以及生物检疫、组织病理学、分析和测序领域的核心。总而言之，科学人才、现有研究环境和新的核心设施的出色结合确保了拟建的中心将进一步促进主题多学科研究中心的发展，增强新研究人员独立竞争补充NIH和其他外部同行审查支持的能力，并加强KUMC现有的生物医学研究基础设施。

Five years of funding are requested to further develop a Center of Biomedical Research Excellence at Kansas University Medical Center with a focus on Nuclear Receptors and their Role in Liver Health and Disease. Five talented new faculty who share this research interest were selected with the goal of helping them become funded, independent investigators. A PI, co-PI, an internal advisory committee of experienced senior faculty and an external advisory committee of prominent scientists have been assembled to mentor them to this goal. The Center will also help provide infrastructure and equipment to supplement the research environment. Ultimately, through the achievement of these initial goals, the final long-range goal is the submission of a program project grant application. An important feature of this Proposal is that for each initial junior faculty member, two co-mentors have been assigned and individual mentoring plans and timetables have been developed. Central features of the mentoring plans include ongoing critical evaluation of the research project by the mentors and IAC, semiannual conferences with EAC members, and special training on statistics, manuscript and grant writing, and teaching. The first 6 junior faculty assigned to this COBRE have competed successfully for independent NIH R01-type research support. The same is expected of the present junior faculty. Once the present junior faculty are funded externally, they will financially rotate off the grant to make room for addition of new junior faculty members. Another important feature of the Proposal is to maintain 4 research Cores to provide additional research support for the Center's faculty. These cores include an administrative Core as well as Cores in the areas of biospecimen, histopathology, analytical, and sequencing. In summary, the outstanding combination of scientific talent, existing research environment, and new core facilities ensure that this proposed Center will further foster the development of a thematic multidisciplinary research center, to enhance the ability of new investigators to compete independently for complementary NIH and other external peer-reviewed support, and to strengthen existing biomedical research infrastructure at KUMC.