Nuclear Receptors in Liver Health and Disease

肝脏健康和疾病中的核受体

• 批准号: 8150136
• 负责人: HARTMUT W. JAESCHKE
• 金额: $ 216.01万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8150136
• 关键词: Nuclear; Receptors; Liver; Health; Disease

DESCRIPTION (provided by applicant): Five years of funding are requested to further develop a Center of Biomedical Research Excellence at Kansas University Medical Center with a focus on Nuclear Receptors and their Role in Liver Health and Disease. Five talented new faculty who share this research interest were selected with the goal of helping them become funded, independent investigators. A PI, co-PI, an internal advisory committee of experienced senior faculty and an external advisory committee of prominent scientists have been assembled to mentor them to this goal. The Center will also help provide infrastructure and equipment to supplement the research environment. Ultimately, through the achievement of these initial goals, the final long-range goal is the submission of a program project grant application. An important feature of this Proposal is that for each initial junior faculty member, two co-mentors have been assigned and individual mentoring plans and timetables have been developed. Central features of the mentoring plans include ongoing critical evaluation of the research project by the mentors and lAC, semiannual conferences with EAC members, and special training on statistics, manuscript and grant writing, and teaching. The first 6 junior faculty assigned to this COBRE have competed successfully for independent NIH ROI-type research support. The same is expected of the present junior faculty. Once the present junior faculty is funded externally, they will financially rotate off the grant to make room for addition of new junior faculty members. Another important feature of the Proposal is to maintain 4 research Cores to provide additional research support for the Center's faculty. These cores include an administrative Core as well as Cores in the areas of biospecimen, histopathology, analytical, and sequencing. In summary, the outstanding combination of scientific talent, existing research environment, and new core facilities ensure that this proposed Center will further foster the development of a thematic multidisciplinary research center, to enhance the ability of new investigators to compete independently for complementary NIH and other external peer-reviewed support, and to strengthen existing biomedical research infrastructure at KUMC.

描述（由申请人提供）：申请五年的资助，以进一步发展堪萨斯大学医学中心的生物医学研究卓越中心，重点研究核受体及其在肝脏健康和疾病中的作用。我们选择了五名有共同研究兴趣的新教师，目的是帮助他们成为有资金支持的独立研究者。为了指导他们实现这一目标，已经召集了一个私人顾问、联合私人顾问、一个由经验丰富的资深教师组成的内部咨询委员会和一个由著名科学家组成的外部咨询委员会。该中心还将帮助提供基础设施和设备，以补充研究环境。最终，通过实现这些初始目标，最终的长期目标是提交计划项目拨款申请。该提案的一个重要特点是，为每个初级教员分配了两位共同导师，并制定了个人指导计划和时间表。指导计划的主要特点包括导师和咨询委员会对研究项目进行持续的批判性评估，与咨询委员会成员举行半年一次的会议，以及关于统计、手稿和拨款写作以及教学的特别培训。分配到该COBRE的前6名初级教师已成功竞争独立的NIH roi型研究支持。对目前的初级教员也是如此。一旦现有的初级教员获得外部资助，他们将在财政上轮换补助金，以便为增加新的初级教员腾出空间。该提案的另一个重要特点是保持4个研究核心，为中心的教师提供额外的研究支持。这些核心包括行政核心以及生物标本，组织病理学，分析和测序领域的核心。总之，科学人才、现有的研究环境和新的核心设施的杰出结合确保了该中心将进一步促进主题多学科研究中心的发展，提高新研究人员独立竞争NIH和其他外部同行评审支持的能力，并加强KUMC现有的生物医学研究基础设施。

项目成果

Mitochondrial superoxide dismutase SOD2, but not cytosolic SOD1, plays a critical role in protection against glutamate-induced oxidative stress and cell death in HT22 neuronal cells.

• DOI: 10.1016/j.freeradbiomed.2009.12.024
• 发表时间: 2010-03-15
• 期刊: FREE RADICAL BIOLOGY AND MEDICINE
• 影响因子: 7.4
• 作者: Fukui, Masayuki;Zhu, Bao Ting
• 通讯作者: Zhu, Bao Ting

Moderate (2%, v/v) Ethanol Feeding Alters Hepatic Wound Healing after Acute Carbon Tetrachloride Exposure in Mice.

• DOI: 10.3390/biom6010005
• 发表时间: 2016-01-06
• 期刊: Biomolecules
• 影响因子: 5.5
• 作者: Deshpande KT;Liu S;McCracken JM;Jiang L;Gaw TE;Kaydo LN;Richard ZC;O'Neil MF;Pritchard MT
• 通讯作者: Pritchard MT

Metabolomic screening and identification of the bioactivation pathways of ritonavir.

• DOI: 10.1021/tx2004147
• 发表时间: 2011-12-19
• 期刊: Chemical research in toxicology
• 影响因子: 4.1
• 作者: Li F;Lu J;Ma X
• 通讯作者: Ma X

Organic anion transporting polypeptides expressed in pancreatic cancer may serve as potential diagnostic markers and therapeutic targets for early stage adenocarcinomas.

• DOI: 10.1007/s11095-012-0962-7
• 发表时间: 2013-09
• 期刊: PHARMACEUTICAL RESEARCH
• 影响因子: 3.7
• 作者: Hays, Amanda;Apte, Udayan;Hagenbuch, Bruno
• 通讯作者: Hagenbuch, Bruno

Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.

• DOI: 10.1016/j.taap.2010.11.002
• 发表时间: 2011-02-01
• 期刊: Toxicology and applied pharmacology
• 影响因子: 3.8
• 作者: Luyendyk JP;Flanagan KC;Williams CD;Jaeschke H;Slusser JG;Mackman N;Cantor GH
• 通讯作者: Cantor GH