Mechanisms of Liver Injury and Diseases

 描述（由申请人提供）：肝脏疾病，包括酒精和药物引起的肝损伤，脂肪肝，病毒性肝炎和肝癌影响着美国数百万人。在过去的9年里，COBRE支持招聘了15名从事肝脏研究的初级教师，并协助堪萨斯大学医学中心发展了非常成功的核心实验室。这些COBRE-supported教师和核心用户发表了500多篇出版物，并产生了超过3800万美元的赠款资金，包括24个R 01赠款。此外，这导致了KUMC肝脏中心和肝脏组织库的建立。总体而言，COBRE第一和第二阶段有助于建立一个蓬勃发展的肝脏研究社区，并创建一个重要的基础设施，以支持肝脏研究和KUMC及其他生物医学研究领域。该申请要求为COBRE的第三阶段提供五年的资金，在此期间，我们将追求以下具体目标：1。为COBRE的成功运作提供行政支持; 2.改善和维持两个科学核心，即人类肝细胞分离核心和分析核心，以提高KUMC和KU教师的研究能力; 3.运行一个试点赠款计划，为追求新的肝脏研究机会和合作提供激励。其结果将是KUMC的高级和中级职业肝脏研究科学家组成的非常强大和高度积极的团队，他们构成了NIH资助的肝脏中心和/或计划项目资助申请的基础。此外，KUMC还协助几个重要的、自我维持的核心实验室，支持肝脏和其他生物医学研究。因此，这次COBRE对KUMC的总体影响将是巨大和持久的。

 DESCRIPTION (provided by applicant): Liver diseases including alcohol- and drug-induced liver injury, fatty liver disease, viral hepatitis, and liver cancer affects millions of people in he US. For the past 9 years the COBRE supported the recruitment of 15 junior faculty engaged in liver research and assisted in the development of highly successful core laboratories at the University of Kansas Medical Center. These COBRE-supported faculty and core users published more than 500 publications and generated more than $38 million of grant funding including 24 R01 grants. In addition, this led to the establishment of a Liver Center at KUMC and a liver tissue bank. Overall, the COBRE Phase I and II were instrumental in establishing a flourishing liver research community and creating an important infrastructure to support liver research and other areas of biomedical research at KUMC and beyond. This application requests five years of funding for the Phase III of this COBRE, during which we will pursue the following specific aims: 1. To provide administrative support for the successful operation of the COBRE; 2.To improve and sustain two scientific cores, the human Liver Cell Isolation Core and the Analytical Core, so that they can enhance the research capabilities of faculty at KUMC and at KU; 3. To operate a pilot grants program to provide incentives for pursuing new liver research opportunities and collaboration. The result will be a very strong and highly motivated group of senior and mid-career liver research scientists at KUMC who form the basis for NIH-funded Liver Center and/or program project grant applications. In addition, KUMC assists several vital, self-sustaining core laboratories that support liver and other biomedical research. Thus, the overall impact of this COBRE at KUMC will substantial and long-lasting.