Mechanisms of Liver Injury and Diseases

 描述(申请人提供)：包括酒精和药物引起的肝损伤、脂肪肝、病毒性肝炎和肝癌在内的肝脏疾病在美国影响着数百万人。在过去的9年里，科布雷支持了15名从事肝脏研究的初级教员的招聘，并协助开发了堪萨斯大学医学中心非常成功的核心实验室。这些Cobre资助的教职员工和核心用户出版了500多种出版物，产生了超过3800万美元的赠款资金，其中包括24笔R01赠款。此外，这导致在KUMC建立了一个肝脏中心和一个肝脏组织银行。总体而言，Cobre第一阶段和第二阶段在建立一个蓬勃发展的肝脏研究社区方面发挥了重要作用，并创建了一个重要的基础设施，以支持KUMC及其他生物医学研究的肝脏研究和其他领域。这项申请为Cobre的第三阶段申请了五年的资金，在此期间，我们将追求以下具体目标：1.为Cobre的成功运营提供行政支持；2.改进和维持两个科学核心，即人肝细胞分离核心和分析核心，以便它们能够增强KUMC和KU的教职员工的研究能力；3.实施试点拨款计划，以激励寻求新的肝脏研究机会和合作。结果将是KUMC的一群非常强大和积极进取的资深和职业生涯中期的肝脏研究科学家，他们构成了NIH资助的肝脏中心和/或项目项目拨款申请的基础。此外，KUMC还协助几个重要的、自给自足的核心实验室，支持肝脏和其他生物医学研究。因此，这一Cobre对KUMC的整体影响将是巨大的和长期的。

 DESCRIPTION (provided by applicant): Liver diseases including alcohol- and drug-induced liver injury, fatty liver disease, viral hepatitis, and liver cancer affects millions of people in he US. For the past 9 years the COBRE supported the recruitment of 15 junior faculty engaged in liver research and assisted in the development of highly successful core laboratories at the University of Kansas Medical Center. These COBRE-supported faculty and core users published more than 500 publications and generated more than $38 million of grant funding including 24 R01 grants. In addition, this led to the establishment of a Liver Center at KUMC and a liver tissue bank. Overall, the COBRE Phase I and II were instrumental in establishing a flourishing liver research community and creating an important infrastructure to support liver research and other areas of biomedical research at KUMC and beyond. This application requests five years of funding for the Phase III of this COBRE, during which we will pursue the following specific aims: 1. To provide administrative support for the successful operation of the COBRE; 2.To improve and sustain two scientific cores, the human Liver Cell Isolation Core and the Analytical Core, so that they can enhance the research capabilities of faculty at KUMC and at KU; 3. To operate a pilot grants program to provide incentives for pursuing new liver research opportunities and collaboration. The result will be a very strong and highly motivated group of senior and mid-career liver research scientists at KUMC who form the basis for NIH-funded Liver Center and/or program project grant applications. In addition, KUMC assists several vital, self-sustaining core laboratories that support liver and other biomedical research. Thus, the overall impact of this COBRE at KUMC will substantial and long-lasting.