Molecular Analysis, Modeling and Correction of Skin Diseases Core Center

描述(申请人提供)：这是国家发改委“皮肤病分子分析、建模和纠正核心中心”的竞争性更新。这是科罗拉多大学安舒茨医学院(UCAMC)的一个基础广泛的项目，有56名成员，其中22名是皮肤科的成员。它的目标是通过分子技术纠正人类皮肤病。该中心的头4年非常成功：国家发改委合作项目或P&F项目的调查人员为机构研究基地增加了20,371,611美元的新研究资金；P&F项目本身在前4年显示出约35倍的投资回报。国家发改委内部的合作已经发表了71篇论文，这些论文得到了研究核心的大力支持。丰富计划和合作管理创建了皮肤病相关研究中强大的研究人员协作网络。在接下来的5年里，我们将把王小星加入我们的领导团队，包括大卫·诺里斯、丹尼斯·鲁普和理查德·斯普里茨。我们将保留5个核心(行政核心、分子遗传分析核心、生物工程核心、形态和表型核心、流式细胞学核心)，但将根据最初4年的资助经验和咨询委员会的建议，对提供的服务进行修改和改进。通过创建全球皮肤病研究联盟来促进国际研究合作并加快将新科学应用到激动人心的转化性研究项目中，充实计划将得到极大的扩展。导师计划“一个新的技术计划，以促进UCAMC-SDRC和全球联盟内的研究。通过增加临床研究团队的新成员，以及在靠近SDRC成员实验室和AMC临床设施的地方建立一个新的GMP设施，将极大地加强使用该SDRC开发的治疗方法的转化性研究。

DESCRIPTION (provided by applicant): This is competing renewal of the SDRC "Molecular Analysis, Modeling and Correction of Skin Diseases Core Center". This is a broad based program on the University of Colorado Anschutz Medical Campus (UCAMC) with 56 members including 22 within the Department of Dermatology. Its goal is the correction of human skin diseases by molecular techniques. The first 4 years of this Center have been highly successful: SDRC investigators in collaborative projects or in P&F projects have added $20,371,611 in new research funding to the Institutional Research Base; The P&F program itself has shown a ~35-fold return on investment during the first 4 years. Collaborations within the SDRC have resulted in 71 published papers that were greatly supported by the Research Cores. The enrichment program and the management of collaborations have created a powerful collaborative network of investigators in skin disease related research. During the next 5 year period, we will add Xiao-Xing Wang to our leadership team of David Norris, Dennis Roop and Richard Spritz. We will retain 5 Cores (Administrative Core, Molecular Genetic Analysis Core, Bioengineering Core, Morphology and Phenotyping Core, and a Flow Cytometry Core), but the services offered will be altered and enhanced based on the experience of the first 4 years of funding, and on the suggestions of the Advisory Committee. The Enrichment Program will be greatly expanded by creating: A Global Skin Diseases Research Consortium to promote international research collaborations and speed the application of new science to exciting translational research projects A Mentorship Program "A New Technology Program to facilitate research within the UCAMC-SDRC and in the Global Consortium. Translational research using treatments developed by this SDRC will be greatly enhanced by addition of new members to the Clinical Investigations Team, and by the availability of a new GMP facility in close proximity to the SDRC member laboratories and clinical facilities on the AMC.