Molecular Analysis, Modeling and Correction of Skin Diseases Core Center

描述（由申请人提供）：这是SDRC“皮肤病分子分析、建模和校正核心中心”的竞争性更新。这是科罗拉多大学安舒茨医学院（UCAMC）的一个基础广泛的项目，有56名成员，其中包括皮肤科的22名成员。其目标是通过分子技术矫正人类皮肤病。该中心的前4年非常成功：SDRC合作项目或P&F项目的调查人员为机构研究基地增加了20，371，611美元的新研究资金; P&F项目本身在前4年的投资回报率约为35倍。SDRC内部的合作已经发表了71篇论文，这些论文得到了研究核心的大力支持。丰富的计划和合作的管理已经创造了一个强大的合作网络的研究人员在皮肤病相关的研究。 在接下来的5年里，我们将把王晓星加入我们的领导团队，包括大卫诺里斯、丹尼斯鲁普和理查德斯普里茨。我们将保留5个核心项目（行政核心项目、分子遗传分析核心项目、生物工程核心项目、形态学和表型分析核心项目以及流式细胞术核心项目），但将根据前4年的资助经验以及咨询委员会的建议，对所提供的服务进行修改和加强。丰富计划将大大扩大通过创建：一个全球皮肤病研究联盟，以促进国际研究合作，并加快新科学的应用，以令人兴奋的转化研究项目一个导师计划“一个新的技术计划，以促进研究内UCAMC-SDRC和全球联盟。 通过向临床研究团队增加新成员，以及在AMC上靠近SDRC成员实验室和临床设施的新GMP设施的可用性，将大大加强使用该SDRC开发的治疗方法的转化研究。

DESCRIPTION (provided by applicant): This is competing renewal of the SDRC "Molecular Analysis, Modeling and Correction of Skin Diseases Core Center". This is a broad based program on the University of Colorado Anschutz Medical Campus (UCAMC) with 56 members including 22 within the Department of Dermatology. Its goal is the correction of human skin diseases by molecular techniques. The first 4 years of this Center have been highly successful: SDRC investigators in collaborative projects or in P&F projects have added $20,371,611 in new research funding to the Institutional Research Base; The P&F program itself has shown a ~35-fold return on investment during the first 4 years. Collaborations within the SDRC have resulted in 71 published papers that were greatly supported by the Research Cores. The enrichment program and the management of collaborations have created a powerful collaborative network of investigators in skin disease related research. During the next 5 year period, we will add Xiao-Xing Wang to our leadership team of David Norris, Dennis Roop and Richard Spritz. We will retain 5 Cores (Administrative Core, Molecular Genetic Analysis Core, Bioengineering Core, Morphology and Phenotyping Core, and a Flow Cytometry Core), but the services offered will be altered and enhanced based on the experience of the first 4 years of funding, and on the suggestions of the Advisory Committee. The Enrichment Program will be greatly expanded by creating: A Global Skin Diseases Research Consortium to promote international research collaborations and speed the application of new science to exciting translational research projects A Mentorship Program "A New Technology Program to facilitate research within the UCAMC-SDRC and in the Global Consortium. Translational research using treatments developed by this SDRC will be greatly enhanced by addition of new members to the Clinical Investigations Team, and by the availability of a new GMP facility in close proximity to the SDRC member laboratories and clinical facilities on the AMC.