Central Control of Mobility in Aging

描述(由申请人提供)：我们建议研究执行控制和疲劳对老年人及其大脑基础的活动能力维持和活动障碍风险的影响。我们的总体工作假设是，在老年人中，机动性、执行控制和疲劳通过额叶皮质-基底节系统紧密联系在一起。我们建议招募450名年龄在70岁及以上的非痴呆症社区居民，在5年的研究期间进行基线和年度随访。将在每一年度评估中实施研究措施，以确定执行控制和疲劳对行动能力的横向和纵向影响(目标1)。功能性近红外光谱(FNIRS)将在每次研究访问中使用，以确定运动中PFC功能与机动性的相关性(目标2)。结构和功能磁共振成像将在基线时应用于亚样本(n=70)，以增强我们对大脑活动相关性的评估。

DESCRIPTION (provided by applicant): We propose to examine the effects of executive control and fatigue on the maintenance of mobility and risk of mobility disability in older adults and their underlying brain substrates. Our overall working hypothesis is that mobility, executive control, and fatigue are closely linked through the frontal cortex-basal ganglia system in older adults. We propose to recruit 450 non- demented community-residing individuals age 70 years and older for baseline and annual follow-ups over the 5-year study period. Study measures will be administered in each yearly evaluation to identify cross-sectional and longitudinal effects of executive control and fatigue on mobility (aim 1). Functional Near Infrared Spectroscopy (FNIRS) will be used in each study visit to identify in motion PFC functional correlates of mobility (aim 2). Structural and functional MRI will be administered to a subsample (n=70) at baseline to augment our assessment of brain correlates of mobility.