Training Program in Stem Cell and Regenerative Developmental Biology

描述（由申请人提供）：我们建议继续在范德比尔特大学发育生物学计划（VENB）的优秀研究/培训环境中持续资助15年的T32计划。VIBR B在一个物理紧凑的网站上代表了多个基础/临床研究项目，具有和谐的互动。优势是：（1）任何受训者都可以轻松访问VIBB教师，并获得学生/研究员对教师的强烈反馈。(2)学生活动（选择访问科学家，研究论坛，年度务虚会，课程中的直接教学机会，RCR学生课程，建设中的研究课程和教学课程培训），以确保学术和社会/管理技能的职业成功。(3)优秀的招聘记录，将学生/博士后放在学术界/行业/教学的领导岗位上。该方案非常重视代表性不足的群体。对受训人员的直接机构支持包括：（1）通过跨学科研究生方案（IGP）资助一年级学生;（2）为行政和培训职能提供VNUB中央资金，否则这些职能将不存在，但却是T32成功的关键。VANDBUS B成员访问最先进的核心：质谱，显微镜，核磁共振成像，生物信息学和许多其他。生物医学研究教育和培训（BRET）办公室协调IGP，MSTP，职业咨询和博士后事务。我们要求8个职位，根据需求，作为培养未来职业培训的优秀人才的一种方式。受训人员在发育生物学的最现代方面进行研究和培训计划，使他们广泛精通“发育”概念，并在临床研究和翻译水平上直接接触人类健康和疾病。研究包括胚胎发生（身体模式，器官发生），器官发生，生理调节，衰老，生殖，癌症和再生。特别强调高分辨率前沿技术，基因组水平分析，表观遗传学，系统生物学和生物信息学，生物统计学，化学生物学，细胞重编程（包括iPS技术）和转分化。受训者在多研究者合作/财团和小型团队导向的努力中体验研究。课程，实验室教学和研讨会发言人都强调发育生物学如何产生对细胞生物学和生物化学以及进化的洞察力。我们利用各种模型系统的研究，依靠在酵母，蠕虫，果蝇，斑马鱼，鸡和小鼠方面的专业知识建立了20年的基础。学生在cor课程学习和实验室轮换的第一年后获得2年的资助，但强制性培训将继续超过2年的正式期限，并以详细的方式正式跟踪学生的进展。培训计划的反馈是来自各级的内部反馈，以及由3名成员组成的外部咨询委员会每周期两次的活动。还提供了以小组讨论和个人访问形式提供的职业培训机会。

DESCRIPTION (provided by applicant): We propose continuation of a continuously funded 15-year T32 Program within the outstanding research/training environment of the Vanderbilt University Program in Developmental Biology (VUPDB). VUPDB represents multiple basic/clinical research programs in a physically compact site, with harmonious interactions. Strengths are: (1) Easy access to VUPDB faculty by any trainee, with strong student/fellow to faculty feedback. (2) Student activities (selecting visiting scientists, research forums, annual retreat, direct teaching opportunities in courses, student courses in RCR, research-in-construction classes, and didactic course training) to ensure academic and social/managerial skills for career success. (3) Excellent record in recruitment, placing students/postdocs in leadership positions in academia/industry/teaching. The Program pays excellent attention to under-represented groups. Direct institutional support for trainees includes: (1) Funding 1st-year students via the Interdisciplinary Graduate Program (IGP); (2) VUPDB central funds for administrative and training functions that otherwise would not exist but are key to T32 success. VUPDB members access state-of-the-art cores for: mass spectrometry, microscopy, NMR imaging, bioinformatics and many others. The Biomedical Research Education and Training (BRET) office co-ordinates IGP, MSTP, Career Counseling, and Postdoctoral Affairs. We request 8 slots, based on demand as a way of turning out outstanding individuals trained for future careers. Trainees undertake a program of research and training in the most modern aspects of Developmental Biology, rendering them widely versed in 'developmental' concepts and giving them a direct exposure to human health and disease at the clinical research and translational levels. Studies encompass embryogenesis (body patterning, organogenesis), organogenesis, physiological regulation, aging, reproduction, and cancer and regeneration. Special emphasis is given to high-resolution frontier technologies, genome-level analyses, epigenetics, systems biology and bioinformatics, biostatistics, chemical biology, cellular reprogramming (including iPS technology), and transdifferentiation. Trainees experience research in multi-investigator collaborative/consortium and small team-oriented efforts. Courses, lab teaching, and seminar speakers all emphasize how developmental biology generates insight into cell biology and biochemistry, and evolution. We leverage studies in various model systems, relying on the 20-year foundation built in expertise in yeast, nematode worms, fruit flies, zebrafish, chicken, and mouse. Students are funded for 2 years after their first year of cor course study and lab rotations, but mandatory training continues past the 2-year formal period, and student progress is formally followed in a detailed manner. Training Program feedback is internal from all levels, as well as by twice-per-cycle activity of a 3-member External Advisory Board. Career training opportunities in the form of group discussions and individual access are also presented.