Epidemiology and Prevention Interdisciplinary Center for Sexually Transmitted Inf

描述（由申请人提供）：尽管有预防和控制公共卫生干预措施，2011年CDC估计美国有1410万新发人乳头瘤病毒（HPV）和286万新发沙眼衣原体（CT）感染病例。虽然这两种感染在大多数女性中都是无症状的，但它们可能会造成严重的健康后果，包括癌症、早产结局、盆腔炎、异位妊娠和不孕。在减少HPV和CT负担方面取得进展的最大希望将来自对当前预防和控制措施的评估与旨在了解当前战略局限性并适应新技术和信息以持续改善结果的基础研究相结合。这项性传播感染合作研究中心（STI-CRC）申请的具体目的是：(1)通过建立性传播感染流行病学和预防跨学科中心（EPIC-STI），扩大目前新墨西哥大学（UNM） STI-CRC的范围；一个专注于HPV和CT感染的中心，通过多学科合作研究方法来解决减少可预防或可治疗性传播感染负担所需的关键知识缺口，(2)资助和支持4个综合和跨学科项目，(a)阐明针对生殖道CT感染的CD4+ t细胞保护性免疫发展的细节；(b)利用新的病毒展示技术制定持久和持久的疫苗战略

DESCRIPTION (provided by applicant): Despite the availability of public health interventions for their prevention and control, in 2011 the CDC estimated 14.1 million new cases of human papillomavirus (HPV) and 2.86 million new cases of Chlamydia trachomatis (CT) infection in the US. While both infections are asymptomatic in most women, they can have serious health consequences including cancer, pre-term pregnancy outcomes, pelvic inflammatory disease, ectopic pregnancy and infertility. The greatest promise for progress in reducing the burden of HPV and CT will result from integration of evaluation of current prevention and control measures with basic research designed to understand limitations to current strategies and adapt new technologies and information for continuous evidence-based improvement in outcomes. The specific aims of this Sexually Transmitted Infection Cooperative Research Center (STI-CRC) application are to (1) expand the scope of the current University of New Mexico (UNM) STI-CRC by establishing the Epidemiology and Prevention Interdisciplinary Center for Sexually Transmitted Infections (EPIC-STI), a center with a focus on HPV and CT infections that incorporates cooperative multidisciplinary research approaches to address key gaps in the knowledge required to reduce the burden of preventable or treatable sexually transmitted infections, (2) fund and support 4 integrated and inter-disciplinary projects that (a) elucidate th details of the development of CD4+ T-cell protective immunity against CT infection of the genital tract, (b) utilize novel virus-display technology to develop vaccine strategies for the durable and effective prevention of HPV and CT infection, (c) use mixed design approaches to characterize the burden of sexually transmitted infection and co-infection in the population as well as the within- and between woman variability of host response to CT infection, and (d) employ unique health informatics systems to delineate the effectiveness of HPV vaccination and evolving cervical cancer screening practices on the burden of STIs and their associated disease outcomes using population-based approaches; 3) Establish two cores that support the EPIC-STI trans-disciplinary research approaches and; 4) contribute to building the next cadre of STI researchers through mentorship and developmental research projects.